ChemInform Abstract: Environmentally Friendly Preparation of Amidoalkyl Naphthols.

Abstract

Naphthols Q 0850Environmentally Friendly Preparation of Amidoalkyl Naphthols. -The novel one-pot, three-component reaction gives higher yields upon thermal heating compared to microwave irradiation. With aliphatic aldehydes, the reaction fails. The preparation of the catalyst from neutral alumina and phosphoric acid is also given. -(SHATERIAN*, H. R.; AMIRZADEH, A.; KHORAMI, F.; GHASHANG, M.; Synth.

Cu(II) immobilized on Fe$_{3}$O$_{4}$@Agarose nanomagnetic catalyst functionalized with ethanolamine phosphate--salicylaldehyde Schiff base: a magnetically reusable nanocatalyst for preparation of 2-substituted imidazolines, oxazolines, and thiazolines

“…1 The largest portion of chemical entities as a part of many natural products, fine chemicals and biologically active pharmaceuticals are made up of nitrogen containing heterocyclic molecules which are vital for enhancing the quality of life. 1 Among a large variety of nitrogen-containing heterocyclic compounds imidazolines, oxazolines, and thiazolines, as an important class of natural and synthetic products, are of interest because many of them exhibit useful biological activities and clinical applications. 2 Moreover, they are known as important intermediates in organic transformations.…”

Green and efficient synthesis of 1H‐indazolo[1,2‐b] phthalazine‐1,6,11(13H)‐triones using ZrO(NO3)2.2H2O as a novel catalyst and theoretical study of synthesized compounds

“…A large group of these compounds includes phthalazine moiety that shows many biological and pharmacological activities such as anticonvulsant, cardiotonic, and vasorelaxant . Sevaral methods have been reported in the literature for the synthesis of 1 H ‐indazolo[1,2‐ b ]phthalazine‐1,6,11(13 H )‐trione derivatives using Mg(HSO 4 ) 2 , [Bmim]Br, p ‐TSA, silica sulfuric acid, silica‐supported polyphosphoric acid, Ce(SO 4 ) 2 ‐4H 2 O, TMSCl, H 3 PW 12 O 40 /IL, H 4 SiW 12 O 40 , N ‐halosulfonamides, Y(OTf) 3, cyanuric chloride, ionic liquids, and Phthalhydrazide 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP), as catalysts. Of course, many of these methods have limitations, such as hard reaction conditions, low yields, relatively long reaction times, and expensive reagents.…”

“…The catalyst ZrO(NO 3 ) 2 .2H 2 O that we used to produce 1 H ‐indazolo[1,2‐ b ]phthalazine‐1,6,11(13 H )‐trione derivatives is important in many respects. Synthesis of these compounds was performed using the catalyst ZrO(NO 3 ) 2 .2H 2 O, which was different from other methods and catalysts with small scale, high speed, and efficiency. Moreover, this catalyst is recyclable and reusable for synthesizing compounds, with only slightly reduced yields.…”

Solvent-free synthesis of 2H-indazolo[2,1-b] phthalazine-triones promoted by cavitational phenomenon using iodine as catalyst

“…Some of the recently developed procedures for the synthesis of 2H-Indazolo[2,1-b]phthalazine trione via a three-component condensation reaction of phthalhydrazide, dimedone, and aromatic aldehydes employing catalyst like H3PW12O40 in ionic liquid [32], H2SO4 in waterethanol or ionic liquid [33], p-TSA [1], N,N,N',N'-tetrabromo benzene-1,3-disulfonamide and poly(N-bromo-N-ethyl benzene-1,3-disulfonamide) [34], (S)-camphorsulfonic acid [35], 1-butyl-3-methylimidazolium bromide [36], and Ce(SO4)2·H2O [37], Me3SiCl [38], silica sulfuric acid [39] and Mg(HSO4)2 [40] and silica supported poly phosphoric acid [41]. Despite the available methods, the development of new simple synthetic routes for the synthesis of phthalazine ring fragment still remains an important challenge, as the reported methods are associated with one or more disadvantages like use of expensive, corrosive or non-biodegradable catalyst, use of solvents, involves additional preparation of catalyst (which makes use of reagents which are corrosive and not easy to handle), high catalyst loading [1,33,[39][40][41] and long reaction time [33].…”