ChemInform Abstract: Evaluation of Some Arylhydrazones (III) of Benzilic Acid Hydrazide (II) as Antimicrobial Agents.

Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy-2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4- substitutedphenyl)methylene]-acetohydrazides

“…The known sequential benzoin, 9 benzil, 10 2-hydroxy-2,2-diphenylacetic acid, 11 ethyl-2-hydroxy-2,2diphenylacetate 12,13,15 and 2-hydroxy-2,2-diphenylacetohydrazide 15 syntheses (Scheme) were conducted according to the literature procedures. A mixture of substituted 2-hydroxy-2,2-diphenylacetohydrazide (6 mmol) and appropriately substituted benzaldehyde (6.6 mmol) was refluxed in absolute ethanol (30 mL) for 4 h. The reaction mixture was checked by TLC on silica gel plate.…”

“…[11][12][13][14] Moderate antibacterial activity of arylhydrazones of benzylic acid reacted with various aryl aldehydes has been mentioned. 15 Recently, there has been considerable interest for the synthesis of substituted acetohydrazide and their thiazolidin-4-one derivatives. These compounds showed a broad biological activities such as anticancer 12,16 , antiviral [17][18][19][20][21] , anticonvulsant 22 , antimycobacterial [23][24][25] , cytotoxic 26 and antifungal.…”

Benzilic acid based new 2-aryl-1,3-thiazolidin-4-one derivatives: Synthesis and anticancer activity

“…2-hydroxy-2,2-diphenylacetic acid ester (0.05 mol) was refluxed with 12 ml of hydrazine hydrate for 12 h. After the reaction was completed, it was poured into a crystallizing dish and left open. The crystals formed thereof were further recrystallized from C2H5OH [27,28].…”

“…A solution of compound 1 (6 mmol ) in ethyl alcohol (30 mL) was refluxed with a suitable aromatic aldehyde (6.6 mmol) for 4 h. The obtained raw precipitate was recrystallized from/washed with ethyl alcohol to yield the desired clean compounds [27][28][29][30].…”

The synthesis and biological activities of 3-acyl- 2,3-dihydro-1,3,4-oxadiazole/ 3-acyl-1,3,4-oxadiazoline derivatives obtained from hydrazide-hydrazones

“…The hydrazide-hydrazones are obtained from the condensation of hydrazides and aldehyde or ketones (1)(2)(3)(4)(5). Also, unsubstituted or monosubstituted hydrazones are converted into hydrazide-hydrazones with acylated agents (1).…”