ChemInform Abstract: Expedient Trimethylaluminum‐Promoted One‐Pot Synthesis of Functional Heteroaromatic and Carbocyclic Trifluoroethylamines.

Abstract

Expedient Trimethylaluminum-Promoted One-Pot Synthesis of Functional Heteroaromatic and Carbocyclic Trifluoroethylamines. -The new method includes the generation of a trifluoromethyl-ketimine from corresponding (hetero)aryl trifluoromethyl ketones and an aniline derivative. Next, the ketimine is subsequently converted into the trifluoroethylamines in a one-pot reaction by addition of borane-methyl sulfide complex. -(ALLENDOERFER, N.; SUDAU, A.; BRAESE*, S.; Adv. Synth. Catal. 352 (2010) 16, 2815-2824, http://dx.