ChemInform Abstract: Gastroprotective Agents for the Prevention of NSAID‐Induced Gastropathy

Abstract

organic chemistry, review organic chemistry, review Z 0200 25 -357 Gastroprotective Agents for the Prevention of NSAID-Induced Gastropathy -[e.g. ebrotidine, quercetin, somatostatin, cisapride, ecabet sodium, xanthine A-906119; 173 refs.]. -(ARES, J. J.; OUTT, P. E.; Curr.

Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3 Receptor

“…The histamine H1 and H2 receptors were identified decades ago [3], [4], and have been shown to be excellent drug targets for the treatment of allergy and gastric ulcers, respectively [5], [6]. The histamine H4 receptor was discovered in 2000 [7], and it has been identified as a potential target for the treatment of inflammatory diseases such as chronic allergies, asthma, atopic dermatitis, and inflammatory bowel diseases [8].…”

“…Histamine, a biogenic amine with multiple physiological effects, exerts its biological activities through four distinct G-protein-coupled receptors (GPCRs) known as the histamine H1, H2, H3, and H4 receptors [1] , [2] . The histamine H1 and H2 receptors were identified decades ago [3] , [4] , and have been shown to be excellent drug targets for the treatment of allergy and gastric ulcers, respectively [5] , [6] . The histamine H4 receptor was discovered in 2000 [7] , and it has been identified as a potential target for the treatment of inflammatory diseases such as chronic allergies, asthma, atopic dermatitis, and inflammatory bowel diseases [8] .…”

Flavonoids as Nutraceuticals: A Review

“…Body cells and tissues are continuously threatened by the damage caused by free radicals and ROS which are produced during normal oxygen metabolism or are induced by exogeneous damage 11,12 . Free radicals and ROS have been implicated in a large number of human diseases 13,14 . Quercetin, kaempferol, morin, myricetin and rutin, by acting as antioxidants, exhibited beneficial effects such as anti-inflammatory, antiallergic, antiviral, as well as anticancer activity.…”

Correction: Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3Receptor

“…Histamine, a biogenic amine with multiple physiological effects, exerts its biological activities through four distinct G-proteincoupled receptors (GPCRs) known as the histamine H1, H2, H3, and H4 receptors [1,2]. The histamine H1 and H2 receptors were identified decades ago [3,4], and have been shown to be excellent drug targets for the treatment of allergy and gastric ulcers, respectively [5,6]. The histamine H4 receptor was discovered in 2000 [7], and it has been identified as a potential target for the treatment of inflammatory diseases such as chronic allergies, asthma, atopic dermatitis, and inflammatory bowel diseases [8].…”