ChemInform Abstract: Hydrophobicity of Several Rhodium(II) Carboxylates Correlated with Their Biologie Activity.

Synthesis, spectral and structural characterization of dinuclear rhodium (II) complexes of the anticonvulsant drug valproate with theophylline and caffeine

“…Among the compounds that have been investigated as antitumor agents were dirhodium tetracarboxylate complexes. The antitumor activity of these complexes was first discovered by Bear et al [4,5] and it was found that the activity of dirhodium tetracarboxylate, Rh 2 (OOCR) 4 , to be in the order: methoxyacetate < acetate < propionate < butyrate [5]. The ability of these complexes to function as antitumor agents against many types of tumors, by inhibiting DNA and protein synthesis, has prompted several studies on the nature of rhodium carboxylates formed with various nucleic acids and their constituent bases in order to elucidate their inhibition properties [1,2,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

“…The coordination chemistry of the dinuclear tetracarboxylate complexes of the transition metals are a focus of interest owing to their wide application in many fields, such as material science, catalysis and as anticancer agents [1][2][3][4][5][6][7][8]. Among the compounds that have been investigated as antitumor agents were dirhodium tetracarboxylate complexes.…”

Apoptosis Induced by Metal Complexes and Interaction withDexamethasone

“…Tumor cells, when exposed to antineoplastic drugs, exhibit apoptosis and alterations of cell cycle phases [1, 2, 3, 4; 5]. These drug effects may have a clinical relevance in acute leukemia patients receiving intensive chemotherapy together with other drugs; for example, effects on acute myeloid (AML) blasts may influence their susceptibility to drug-induced apoptosis, and effects on T cells may alter effector functions that mediate additional antileukemic effects in patients receiving intensive chemotherapy 6, Since the initial discovery of the antineoplastic activity of cisplatin several metal complexes including those of rhodium have been tested and some exhibited antitumor activity [7,8,9,10,11,12,13,14].…”

Distribution of Rhodium in Mice Submitted to Treatment With the Adduct of Rhodium Propionate and Sodium Isonicotinate

“…The pharmacological evaluations of rhodium carboxylates (rhodium acetate, propionate and butyrate), have shown statistically significant activity against Ehrlich ascites carcinoma, melanoma B16, leukemia P388 and leukemia L1210 [2,7,8]. The activity was found to be in the order: acetate < propionate < butyrate; rhodium(ll) propionate having a more interesting therapeutic index.…”