ChemInform Abstract: Influence of Curcumin Treatment on Collagen Metabolism in Experimental Myocardial Necrosis in Rats

Nirmala, Chandrasekar; Anand, Selvaraj; Puvanakrishnan, Rengarajulu

doi:10.1002/chin.199930316

Cited by 8 publications

(8 citation statements)

References 1 publication

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“…[29][30][31] It has also shown that curcumin pre-and post-treatment exerts membrane stabilizing action by decreasing the degradation of collagen matrix by inhibiting the release of lysosomal enzymes. [32][33][34] In contradiction to this, there are in vitro studies which suggests curcumin's prooxidant potential. 16,17,35 However, data in support of its in vivo toxic effects remain unavailable.…”

Section: Discussionmentioning

confidence: 87%

Dose‐dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence

Tanwar

Sachdeva

Kishore

et al. 2009

Cell Biochemistry & Function

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Curcumin, an active component of turmeric, is a well-known antioxidant due to its reactive oxygen species (ROS) scavenging property. However, some in vitro studies have suggested that curcumin induces generation of ROS at higher doses and thus exerts pro-oxidant effect. We demonstrate, for the first time, the dose-dependent effects of curcumin in isoprenaline-induced model of myocardial necrosis in rats. The animals were assigned to control, isoprenaline and three curcumin treatment groups. Curcumin (100, 200, and 400 mg/kg) and vehicle (dimethyl sulfoxide) were administrated orally for 15 days and isoprenaline (85 mg/kg, s.c.) was given to curcumin treated and isoprenaline group on 13th and 14th day, respectively. Thereafter, on 15th day, the animals were sacrificed for biochemical analysis along with histopathological and ultrastructural examination. There was an increase in glutathione, superoxide dismutase (SOD), creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) levels, decrease in thiobarbituric acid reactive substances (TBARS), and preservation of myocardial architecture in the curcumin (100 and 200 mg/kg) treated groups. However, at 400 mg/kg dose there was ineffectual protection against isoprenaline-induced myocardial damage. Instead, there was significant lipid peroxidation as evident by increased levels of TBARS (93.87 +/- 9.93, p < 0.0001) and decrease in CK-MB (206.32 +/- 13.54, p < 0.0001) and LDH (134.26 +/- 9.13, p < 0.01) as compared to the two lower doses. Hence, it can be concluded that curcumin augments endogenous antioxidant system at lower doses but mediates ROS induction at higher concentration leading to myocardial damage.

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Section: Discussionmentioning

confidence: 87%

Dose‐dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence

Tanwar

Sachdeva

Kishore

et al. 2009

Cell Biochemistry & Function

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“…The model is characterized by an extraordinary technical simplicity, an excellent reproducibility as well as an acceptable low mortality [6]. Myocardial infarction induced by ISO has been reported to show many metabolic and morphological aberrations in the heart tissue of the experimental animals similar to those observed in human myocardial infarction [7]. ISO induced necrosis is maximal in the subendocardial region of the left ventricle and in the intraventricular septum [8].…”

Section: Isoproterenol Induced Myocardial Infarctionmentioning

confidence: 99%

Cardio Protective Action of Cilostazol, Milrinone and Their Combination over Isoproterenol Induced Myocardial Infarction in Wistar Rats

Dhakad¹,

Sharma²,

Kumar³

et al. 2017

ijccd

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The cardio protective action of cilostazol, milrinone and their combination effect on myocardial infarction induced by isoproterenol subjected to Wistar rats was done by studying various parameters-heart rate, % infarct size change, LDH level, CPKMB level, ECG pattern. In the following research work effect of synthetic drugs cilostazol, milrinone and their combined effect were studied over various biochemical and cardiac parameters. Isoproterenol was used in inducing myocardial infarction to Wistar rats. Isoproterenol (15 mg/100g) administration, causes an increased levels of biochemical markers-lactate dehydrogenase (2546.25±1.38), creatine phosphokinase (1485.5±.80) in serum of rats indicating potential action of isoproterenol on myocardium. Due to necrosis of myocardium a marked increase of these enzymes was seen in blood. A significant decrease in heart rate (262±.96) in isoproterenol treated rats was observed. Infarct size in ISO group rats (41%±.008) increased to certain extent with promiscuous yellow colored non-viable cells visible indicating infarction. Statistical analysis done by one-way ANOVA followed by the Dunnett's multiple comparison test where ISO control group compared with other groups, p value < 0.001 indicating extremely significant results. The present study demonstrated pharmacological benefits of combination dose of cilostazol, milrinone as evidenced by improvement in heart rate, Lactate dehydrogenase level, Creatine phosphokinase MB level, Electrocardiogram pattern, % infarct size.

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“…In isoproterenol‐induced myocardial necrosis models, curcumin has been reported to have significant effects on the prevention of collagen synthesis (Nirmala, Anand, & Puvanakrishnan, ). Moreover, histopathologic findings also showed that curcumin treatment decreased the degree of myocardial necrosis in isoproterenol‐treated rats (Nazam Ansari, Bhandari, & Pillai, ; Nirmala & Puvanakrishnan, ).…”

Section: Antioxidative and Anti‐inflammatory Properties Of Curcumin Imentioning

confidence: 99%

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

Miao

et al. 2019

Phytotherapy Research

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It has been extensively verified that inflammation and oxidative stress play important roles in the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma longa, have three major active ingredients, which include curcumin (curcumin I), demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have been used in traditional medicine for CVDs' management and other comorbidities for centuries. Numerous studies had delineated their anti‐inflammatory, antioxidative, and other medicinally relevant properties. Animal experiments and clinical trials have also demonstrated that turmeric and curcuminoids can effectively reduce atherosclerosis, cardiac hypertrophy, hypertension, ischemia/reperfusion injury, and diabetic cardiovascular complications. In this review, we introduce and summarize curcuminoids' molecular and biological significance, while focusing on their mechanistic anti‐inflammatory/antioxidative involvements in CVDs and preventive effects against CVDs, and, finally, discuss relevant clinical applications.

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ChemInform Abstract: Influence of Curcumin Treatment on Collagen Metabolism in Experimental Myocardial Necrosis in Rats

Cited by 8 publications

References 1 publication

Dose‐dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence

Dose‐dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence

Cardio Protective Action of Cilostazol, Milrinone and Their Combination over Isoproterenol Induced Myocardial Infarction in Wistar Rats

Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases

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