ChemInform Abstract: Intermolecular 1,3‐Dipolar Cycloaddition of Nitrile Oxides with Vinyl Acetate and Acrylonitrile.

Abstract

Intermolecular 1,3-Dipolar Cycloaddition of Nitrile Oxides with Vinyl Acetate and Acrylonitrile. -Reaction of preformed nitrile oxides (II) with vinyl acetate and acrylonitrile provides the expected cycloadducts (cf. (VI) and (IV), resp.) in better yields compared to analogous reactions of nitrile oxides generated in situ. -(RAI, K. M. L.; HASSNER, A.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 36 (1997) 3, 242-245; Dep. Stud.

Novel Isoxazoline-1, 2, 4-oxadiazoles: Synthesis, Characterization and Antimicrobial screening

“…After the period of incubation the inhibition zones were measured in mm (Table.1). Synthesis of 3-phenyl-4,5-dihydroisoxazole-5-carbonitriles (2a-c): (Rai, 1997): Isoxazole-5-carbonitrile 2a was achieved by refluxing aldoxime (1a, 1.0g, 0.0082 mol) and acrylonitrile (1.3g, 0.0246 mol) with oxidizing agent chloramine-T (2.77 g, 0.0098 mol) in alcohol for about 3h to give a white solid isoxazole-5-carbonitrile (2a, 1.10g). Synthesis of (Z)-N'-hydroxy-3-phenyl-4, 5-dihydroisoxazole-5-carboximidamide (3a-c): (Srikantamurthy, 2013): A mixture of isoxazole-5-carbonitrile (2a, 1.0g, 0.0058 mol), NH2OH.HCl (2g) and Na2CO3 (2g) in dilute ethanol (50%) were refluxed on water bath for about 4 to 5 hours to give light yellow solid isoxazoline-amidoxime (3a.…”

Synthesis and Antimicrobial Activity of a New Class of Sulfone Linked Bisheterocycles

“…Indeed, diazomethane, nitrile imines and nitrile oxides have been used extensively as reactive intermediates. The nitrile imines and nitrile oxides can be generated by dehydrogenation of araldehyde phenylhydrazones and araldoximes with lead tetraacetate [16], mercuric acetate [17], 1-chlorobenzotriazole [18], chloramine-T [19][20][21][22] etc. The present communication deals with the synthesis of sulfone linked bis heterocycles having a pyrrole in combination with a pyrazole or an isoxazole unit.…”