ChemInform Abstract: KAl(SO₄)₂·12H₂O(Alum): An Efficient Catalyst for the Synthesis of Novel Bis[spiro(quinazoline‐oxindole)] Derivatives via One‐Pot Pseudo Five‐Component Reactions.

Abstract

KAl(SO 4)2·12H2O(Alum): An Efficient Catalyst for the Synthesis of Novel Bis[spiro(quinazoline-oxindole)] Derivatives via One-Pot Pseudo Five-Component Reactions. -The applied catalyst can be reused at least for four times. -(MOHAMMADI*, A. A.; TAHERI, S.; ASKARI, S.; AHDENOV, R.; J. Heterocycl. Chem. 52 (2015) 6, 1871-1875, http://dx.

Recent Developments on Five-Component Reactions

“…The Nikoofar group recently employed multi-layered nano [(Asp-Gua) IL@PEG-SiO2] catalyst for the synthesis of bis(2-phenyl-2,3-dihydroquinazolin-4(1H)-one) derivatives using p-phenylenediamine as a 2-centered reactant [19]. The Mohammadi group developed a 6C5CR for the synthesis of novel bis[spiro(quinazoline-oxindole)] derivatives 81 using two equiv each of isatoic anhydride and isatins and one equiv of diamines under the catalysis of alum (KAl(SO4)2 • 12H2O) (Scheme 33) [48]. The condensation of two isatoic anhydride with ethylenediamine followed by second condensation with isatins give iminoisatins 82 after dehydration.…”

“…The Mohammadi group developed a 6C5CR for the synthesis bis[spiro(quinazoline-oxindole)] derivatives 81 using two equiv each of isatoic and isatins and one equiv of diamines under the catalysis of alum (KAl(SO (Scheme 33) [48]. The condensation of two isatoic anhydride with ethylened lowed by second condensation with isatins give iminoisatins 82 after dehydr intramolecular nucleophilic additions of 82 lead to the formation of products 81 Scheme 32.…”

“…• 12H 2 O) (Scheme 33) [48]. The condensation of two isatoic anhydride with ethylenediamine followed by second condensation with isatins give iminoisatins 82 after dehydration.…”