ChemInform Abstract: Lipase‐Catalyzed Reactions in Ionic Liquids.

Lau, Rute Madeira; Rantwijk, Fred van; Seddon, K. R.; Sheldon, Roger A.

doi:10.1002/chin.200112039

Cited by 12 publications

(18 citation statements)

References 1 publication

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“…[8][9][10][11] Furthermore, many liquid-liquid phase equilibrium systems such as IL/water and IL/ organic solvent systems have been presented; this indicates the possibility of utilizing ILs as reaction or extraction solvents. [12][13][14][15] For example, it has been shown that 1-alkyl-3-methylimidazolium bis(trifluoromethane sulfonyl)amide ([C n mim][NTf 2 ]), a typical hydrophobic IL, can be used for the extraction of aromatic compounds from aliphatic hydrocarbons.…”

Section: Introductionmentioning

confidence: 99%

Structural effects of polyethers and ionic liquids in their binary mixtures on lower critical solution temperature liquid-liquid phase separation

Kodama

Tsuda

Niitsuma

et al. 2011

Polym J

103

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The solubility and phase behavior of five polyethers (poly(ethylene oxide), poly(glycidyl methyl ether), poly(ethyl glycidyl ether), poly(ethoxyethyl glycidyl ether) and poly(propylene oxide)) in 14 different room-temperature ionic liquids (ILs) were studied by changing the structures of polyethers and the cations and anions in the ILs. Certain combinations of a polyether and an IL binary mixture exhibited lower critical solution temperature (LCST) phase behavior. For ILs containing the same anions, the polyethers were highly soluble in imidazolium-or pyridinium-based ILs, whereas they were insoluble in ammonium-or phosphonium-based ILs. An increase in length of the alkyl chain in the imidazolium cation and an increase in polarity of the polyethers resulted in a higher LCST phase separation temperature, whereas substitution of the hydrogen atoms on the imidazolium ring by methyl groups resulted in a lower LCST phase separation temperature. The hydrogen bonding interaction between the oxygen atoms in the polyethers and the aromatic hydrogen atoms on the cations in the ILs had an important role in the LCST phase behavior of the mixtures. Miscibility of the mixtures was also affected by the Lewis basicity of the anions in the ILs.

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Section: Introductionmentioning

confidence: 99%

Structural effects of polyethers and ionic liquids in their binary mixtures on lower critical solution temperature liquid-liquid phase separation

Kodama

Tsuda

Niitsuma

et al. 2011

Polym J

103

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“…Biocatalysis in ionic liquids was first reported in Cull et al (2000) and Lau et al (2000) and studies that deal with this theme claim that these systems show a higher selectivity, higher rate and greater enzyme stability. In biodiesel production, the support of enzymes in ionic liquids has been developed aiming to overcome problems associated with conventional enzymatic transesterification, such as enzyme deactivation by some alcohols, particularly methanol, and blockage of active sites of the enzyme by glycerol, which decreases their activity and inhibits the reuse of the biocatalyst.…”

Section: Ionic Liquids As Supports For Enzymatic Catalysismentioning

confidence: 99%

Use of ionic liquids in biodiesel production: a review

Andreani

Rocha

2012

Braz. J. Chem. Eng.

121

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-This paper discusses the feasibility of the use of ionic liquids as catalysts in the biodiesel production field, describing some studies already published in the literature on this theme. Ionic liquids are regarded as a new generation of catalysts in the chemical industry, with several uses in different commercial segments. However only a few publications involving this topic can be found in the literature addressing the manufacture of biodiesel from vegetable oils or animal fats. Through the analysis of the data generated in the studies reviewed, it is possible to affirm that ionic liquids present great potential as catalysts for biodiesel production, but there are some challenges to be faced, such as the production of ionic liquids with low cost, easy recovery and with the possibility of reutilization of the catalyst for several cycles.

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“…The use of enzymes, especially lipases, in ionic liquids, has demonstrated many advantages, such as high conversion rates, good enantioselectivity, better recoverability and recyclability. For example, the stability of lipases such as CaLB [13][14][15][16] and Pseudomonas cepacia lipase (PcL) [15,17] are catalytically active in imidazolium and pyridinium ILs containing BF 4´, PF 6´a nd Tf 2 N´ [14]. [OmPy][BF 4 ] provide high enantioselectivity to hesperidinase when used as co-solvent in the enzymatic conversion of rutin to isoquercitrin.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Hydrolytic Resolution of Racemic Ibuprofen Ethyl Ester Using an Ionic Liquid as Cosolvent

et al. 2016

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Abstract:The aim of this study was to develop an ionic liquid (IL) system for the enzymatic resolution of racemic ibuprofen ethyl ester to produce (S)-ibuprofen. Nineteen ILs were selected for use in buffer systems to investigate the effects of ILs as cosolvents for the production of (S)-ibuprofen using thermostable esterase (EST10) from Thermotoga maritima. Analysis of the catalytic efficiency and conformation of EST10 showed that [OmPy] [BF 4 ] was the best medium for the EST10-catalyzed production of (S)-ibuprofen. The maximum degree of conversion degree (47.4%), enantiomeric excess of (S)-ibuprofen (96.6%) and enantiomeric ratio of EST10 (177.0) were achieved with an EST10 concentration of 15 mg/mL, racemic ibuprofen ethyl ester concentration of 150 mM, at 75˝C , with a reaction time of 10 h. The reaction time needed to achieve the highest yield of (S)-ibuprofen was decreased from 24 h to 10 h. These results are relevant to the proposed application of ILs as solvents for the EST10-catalyzed production of (S)-ibuprofen.

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ChemInform Abstract: Lipase‐Catalyzed Reactions in Ionic Liquids.

Cited by 12 publications

References 1 publication

Structural effects of polyethers and ionic liquids in their binary mixtures on lower critical solution temperature liquid-liquid phase separation

Structural effects of polyethers and ionic liquids in their binary mixtures on lower critical solution temperature liquid-liquid phase separation

Use of ionic liquids in biodiesel production: a review

Enzymatic Hydrolytic Resolution of Racemic Ibuprofen Ethyl Ester Using an Ionic Liquid as Cosolvent

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