ChemInform Abstract: MEDICINAL APPLICATIONS OF INDOLE DERIVATIVES

Sugden, J. K.; Yoloye, T. O.

doi:10.1002/chin.197903333

Cited by 8 publications

(7 citation statements)

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“…These heterocyclic Schiff bases have the added advantages of: ease of synthesis, electronic properties, higher solubility in organic solvents and most importantly for their potential role as chelating ligands in coordination chemistry [18]. The 1,2,4-triazole motif is a part of a large number of chemotherapeutic drugs [19,20] which are useful as: anti-inflammatory [21,22], anti-depressant, antiviral, antifungal, antimicrobial [23][24][25][26][27], anticancer properties [28][29][30][31], antitubercular [32][33][34][35] and analgesic [36], activities. Owing to the huge possibility of exploration of biologically active molecules containing this moety, a lot of work has been done on the synthesis of 1,2,4-triazole Schiff base derivatives [37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

et al. 2020

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A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino-and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1 HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.

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Section: Introductionmentioning

confidence: 99%

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

et al. 2020

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“…Indole and its derivatives represent several biological activities such as anti-fungal, anti-bacterial, anti-viral, anti-cancerous, anti-HIV, anti-oxidant, insecticidal, anti-tubular, plant growth regulator, plasmid stability, spore formation, biofilm formation, resistance to drugs and precursor for neurotransmitter serotonin formation etc. [88][89][90]. Because of the association of extensive π-electrons in the form of four double bond and two non-bonding electrons of pyrrole's nitrogen, indole and its derivatives are supported to show strong interactions with the metallic surface [42,91].…”

Section: Indole Based Alkaloids As Corrosion Inhibitorsmentioning

confidence: 99%

Alkaloids as green and environmental benign corrosion inhibitors: An overview

2019

Int. J. Corros. Scale Inhib.

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Alkaloids are naturally occurring nitrogen containing organic bases that possess diverse and significant physiological effects on animals and humans. They are mostly derived from the plants. Because of their natural and biological origin, they (alkaloids) are considered as environmental benign alternatives to be used as corrosion inhibitors at the place of traditional and toxic synthetic corrosion inhibitors. Numerous alkaloids have been employed as effective corrosion inhibitors for metals and alloys in different electrolytic media. It has been established that alkaloid molecules are associated with extensive conjugation in the form of non-bonding and π-elections through which they can interact strongly and inhibit corrosion efficiently. Present review article features the collection of reports published on the topic alkaloids as corrosion inhibitors. In this review article, we also described the corrosion and its adverse effect, mechanism of corrosion and corrosion inhibition by organic corrosion inhibitors (including alkaloids) and factors affecting the inhibition property of corrosion inhibitors. Literature study suggests that most of the alkaloids are soluble in the polar electrolytic media and thereby behave as good corrosion inhibitors. Present review article describes the inhibition effect of several classes of alkaloids such as pyridine, purine and indole derivatives that have been used previously. Chemical structures alkaloids and their mode of adsorption and interactions with the metallic surface, nature of metal and electrolyte and related salient features have also been tabulated in the review.

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“…The tas moiety was chosen as a linker not only because of its structural versatility but also for its range coordination chemistry due to its diverse coordination modes . It is noted that triazole derivatives are well known to exhibit anti‐inflammatory, anti‐viral, analgesic, anti‐convulsant and anti‐depressant activities.…”

Section: Introductionmentioning

confidence: 99%

Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)–2,2′:6′,2″‐terpyridine with rigid dianionic 1,2,4‐triazole‐3‐sulfonate linker

Büyükekşi

Erkısa

Şengül

et al. 2018

Applied Organom Chemis

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A new dinuclear coordination compound of palladium(II), [Pd2(terpy)2(μ‐tas‐N1,N4)]SO4⋅11H2O (1), was synthesized by tethering a doubly deprotonated 1,2,4‐triazole‐3‐sulfonate (tas) linker generated in situ via oxidation of 1,2,4‐triazole‐3‐thione (tat) under the synthetic conditions. X‐ray diffraction analysis reveals that tat molecules adopt the thione form in the solid state, and are combined in infinite chains by symmetrically related classical intermolecular hydrogen bonds N1─H1⋅⋅⋅S1, N3─H3⋅⋅⋅N2 to give rise to R22(7) pattern in one‐dimensional chains along the b‐axis propagating along the a‐axis. Further short contacts through lone pairs of N2⋅⋅⋅S1 on the rings between the adjacent chains along the a‐axis lead to a two‐dimensional network structure. Compound 1 was characterized using infrared, 1H NMR and UV–visible spectroscopies, electrospray ionization mass spectrometry and X‐ray crystallography. The crystal structure determination of 1 reveals that the Pd(II) ions are coordinated with four nitrogen atoms: three from terpy and one from tas acting as an end‐to‐end (μ‐1,4) bridging ligand. The Pd(II) ions in 1 adopt a distorted square planar geometry. The anti‐growth effect of 1 was tested on colorectal cancer (HCT‐15), non‐small‐cell lung cancer (A549), prostate cancer (PC‐3) and cervical cancer (HeLa) cell lines using sulforhodamine B viability assay. The cytotoxic effect was further confirmed using adenosine triphosphate viability assay. Compound 1 shows a promising cytotoxic activity in the diverse cancer cell models in vitro (p <0.0001).

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ChemInform Abstract: MEDICINAL APPLICATIONS OF INDOLE DERIVATIVES

Abstract: Review: Übersichtsarbeit über die pharmakolc gische Anwendung von Indolderivaten in der Medizin.

Cited by 8 publications

References 0 publications

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents

Alkaloids as green and environmental benign corrosion inhibitors: An overview

Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)–2,2′:6′,2″‐terpyridine with rigid dianionic 1,2,4‐triazole‐3‐sulfonate linker

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