ChemInform Abstract: Meglumine Catalyzed Expeditious Four‐Component Domino Protocol for Synthesis of Pyrazolopyranopyrimidines in Aqueous Medium.

Abstract

Meglumine Catalyzed Expeditious Four-Component Domino Protocol for Synthesis of Pyrazolopyranopyrimidines in AqueousMedium. -A facile and highly efficient protocol for the one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes, and barbituric acid has been developed using meglumine as an inexpensive, biodegradable, and reusable catalyst. This methodology provides a mild and fast route to structurally diverse tricyclic fused pyrazolopyranopyrimidines in good to excellent yields. Simplicity, room temperature reaction conditions, a green solvent, an easy work-up process, inexpensive price, and reusability of the catalyst are the main advantages of this method. -(LI, X.-T.; ZHAO, A.-D.; MO, L.-P.; ZHANG*, Z.-H.; RSC Adv. 4 (2014) 93, 51580-51588, http://dx.doi.org/10.1039/C4RA08689A ; Coll. Chem. Mater. Sci., Hebei Norm. Univ., Shijiazhuang 050024, Peop. Rep. China; Eng.) -B. Guendogan 15-232