ChemInform Abstract: New Antitumor Hydroxymethyl Derivatives of Vinblastine.

Abstract

New Antitumor Hydroxymethyl Derivatives of Vinblastine. -New hydroxymethyl derivatives of the antitumor indole-indoline alkaloids vinblastine and leurosine are prepared by simple reduction of an ester group in the parent alkaloids [→ (II)] or by coupling of the monomer alkaloid catharanthine (VI) with vindoline derivatives [→ (VII)]. Among the new vinblastine derivatives, compound (II) shows highest cytotoxic activity. -(BOELCSKEI, H.; SZAN-TAY, C. JUN.; MAK, M.; BALAZS, M.; SZANTAY, C.; J. Indian Chem.

Voltammetry of an Anti-cancer Drug

“…The dinitro-derivatives of leurocine and vinblastine were prepared for pharmacological investigation. The coupling of catharanthine and vindoline was done either by selective reduction of deacetoxyvinblastine or by ferric chloride mediated coupling reaction of catharanthine and the corresponding vindoline derivatives (6).…”