Voltammetry of an Anti-cancer Drug

Haque, Inam ul; Saba, Hina

doi:10.1149/1.3099679

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, despite the redox active groups in the molecular structure of Vinca alkaloids, very few studies have been reported on their electrochemical properties due to their very complex structure [9-15]. Considering that voltammetry, which is one of the electroanalytical methods, is simple, fast, low cost, low sensitive to matrix effect and suitable for on-site analysis; it is clear that this method will be an alternative candidate for the determination of these antineoplastic drugs in the near future [16][17][18].…”

Section: Article Info Abstractmentioning

confidence: 99%

Electroanalytical Investigation of Cancer Chemotherapy Drug Vinorelbine On Disposable Pencil Graphite Electrode in Surfactant Media by Voltametric Method

Önal

Levent

Şentürk

2023

EJT

View full text Add to dashboard Cite

One of the biggest global public health issues, cancer has a negative impact on people's health and quality of life. Therefore, it is undeniable that the interest in drugs for cancer treatment has increased. On the other hand, in addition to patient safety during the administration of drugs used in cancer treatment due to their possible toxic properties, it is crucial to maintain a safe working environment and to safeguard the health professionals who provide the treatment from the possibility of coming into touch with this class of medications. At the same time, it is extremely important to develop methods for the analysis of antineoplastic drugs in different environments. In this study, a new application of disposable pencil-tip graphite electrode for the determination of Vinorelbine, which is one of the semi-synthetic derivatives of Vinca alkaloids, which is in the class of herbal antineoplastic drugs used in cancer treatment, is presented. Using a pencil-tip graphite electrode, the CV and SWV techniques were used to examine the electrochemical characteristics of vinorelbine throughout a large pH range (2.0-12.0), both without and with surfactant medium. Vinorelbine in BR (pH=10.0) buffer containing 3 mM cationic surfactant (tetra-n-butylammonium bromide) by SW-AdSV technique, it responded voltammetrically with a potential of +0.75 V. The suggested technique has been used successfully with human urine samples that have been spiked with vinorelbine and medication formulations.

show abstract

Section: Article Info Abstractmentioning

confidence: 99%

Electroanalytical Investigation of Cancer Chemotherapy Drug Vinorelbine On Disposable Pencil Graphite Electrode in Surfactant Media by Voltametric Method

Önal

Levent

Şentürk

2023

EJT

View full text Add to dashboard Cite

show abstract

A label-free electrochemical biosensor based on tubulin immobilized on gold nanoparticle/glassy carbon electrode for the determination of vinblastine

et al. 2017

View full text Add to dashboard Cite

Vinblastine (VLB) is prescribed for a wide variety of cancers. Therefore, development of sensitive methods for early diagnosis is urgently required. In this work, a highly sensitive and label-free impedimetric biosensor was fabricated for the electrochemical detection of VLB. First, the gold nanoparticles (AuNPs) were electrodeposited on the surface of a glassy carbon electrode (GCE). 3-Mercaptopropionic acid (MPA) was self-assembled over the AuNPs. Then, tubulin (TUB), as a receptor, was covalently immobilized at the AuNPs/GCE surface via carbodiimide coupling reaction using N-(3 dimethylaminopropyl)-N'-ethyl carbodiimide (EDC) and N-hydroxy succinimide (NHS). The step-by-step modification process was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in the presence of a redox probe [Fe(CN)]. The VLB concentration was measured through the increase of impedance values in the corresponding specific binding of VLB and TUB. The increased electron-transfer resistance (R ) values were proportional to the value of VLB concentrations in the range of 0.4 to 65.0 nmol L with a detection limit of 8.4 × 10 nmol L (SN = 3). The practical analytical performance of the proposed method was demonstrated by determination of VLB in plant extracts and human serum samples with satisfactory recoveries.

show abstract

Anti-Kanser İlaç Vinblastin’in Kalem Grafit Elektrot Yüzeyinde Elektrokimyasal Özelliklerinin İncelenmesi Ve Miktar Tayini

Önal

2023

Afyon Kocatepe University Journal of Sciences and Engineering

View full text Add to dashboard Cite

Kanser kemoterapisinde kullanılan vinblastin (VNB) antineoplastik bir ilaçtır. Sunulan bu çalışmada, VNB‘nin elektrokimyasal özellikleri tek kullanımlık kalem grafit (PG) elektrot ile geniş bir pH aralığında ve farklı destek elektrolitler ‘’Britton–Robinson (0.04 M BR, pH 2.0-12.0), fosfat (0.04 M PBS, pH 2.0, 3.0, 4.0, 7.4) ve asetat ( 0.04 M ABS, pH 4.8) içinde döngüsel voltametri ‘’CV’’ ve Kare Dalga Voltametri ‘’SWV’’ teknikleriyle incelenmiştir. VNB, +0.993 V gerilim ve 3.844 µA akım değerinde BR (pH 2.0) içinde CV ile tersinmez bir yükseltgenme piki vermiştir. SWV tekniği ile anodik akım sinyali, BR (pH 2.0) içerisinde 11 nM ile 495 nM arasında derişim ile doğrusal bir korelasyon gösterdi ‘’Ip (µA) = 0.0087 C (nM) - 0.3448 (r = 0.993, n = 12)’’ . 11 nM derişim seviyesinde, 2.4 nM gözlenebilme sınırı (LOD) ve % 2.93 göreli standart sapma hesaplandı. Önerilen yöntemin analitik uygulaması ilaç ve idrar örneklerinde pratik edilmiş ve geri kazanımlarla gösterilmiştir.

show abstract

Voltammetry of an Anti-cancer Drug

Cited by 3 publications

References 17 publications

Electroanalytical Investigation of Cancer Chemotherapy Drug Vinorelbine On Disposable Pencil Graphite Electrode in Surfactant Media by Voltametric Method

Electroanalytical Investigation of Cancer Chemotherapy Drug Vinorelbine On Disposable Pencil Graphite Electrode in Surfactant Media by Voltametric Method

A label-free electrochemical biosensor based on tubulin immobilized on gold nanoparticle/glassy carbon electrode for the determination of vinblastine

Anti-Kanser İlaç Vinblastin’in Kalem Grafit Elektrot Yüzeyinde Elektrokimyasal Özelliklerinin İncelenmesi Ve Miktar Tayini

Contact Info

Product

Resources

About