ChemInform Abstract: New Phytotoxic Metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee Gut.

Zhang, Ying Lao; Ge, Hui; Li, Fang; Song, Yong; Tan, Ren Xiang

doi:10.1002/chin.200912209

Cited by 6 publications

(8 citation statements)

References 13 publications

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“…Many species of Pestalotiopsis are saprobes, while others are pathogenic or endophytic on living plant leaves and twigs [9]. Some Pestalotiopsis species have gained much attention in recent years as they produce many important secondary metabolites with potential use in medical applications and Cultivations were conducted at 30°C and pH 6.5 in 250-ml Xasks containing 100 ml of YEPX broth without shaking for 72 h. Biomass were measured as dry weight in the control of plant diseases [14,18,26]. No reports showed that Pestalotiopsis species were pathogenic to humans.…”

Section: Discussionmentioning

confidence: 99%

Fermentation of xylose into ethanol by a new fungus strain Pestalotiopsis sp. XE-1

Pang

Liang

Huang

2010

J Ind Microbiol Biotechnol

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A new fungus, Pestalotiopsis sp. XE-1, which produced ethanol from xylose with yield of 0.47 g ethanol/g of consumed xylose was isolated. It also produced ethanol from arabinose, glucose, fructose, mannose, galactose, cellobiose, maltose, and sucrose with yields of 0.38, 0.47, 0.45, 0.46, 0.31, 0.25, 0.31, and 0.34 g ethanol/g of sugar consumed, respectively. It produced maximum ethanol from xylose at pH 6.5, 30°C under a semi-aerobic condition. Acetic acid produced in xylose fermenting process inhibited ethanol production of XE-1. The ethanol yield in the pH-uncontrolled batch fermentation was about 27% lower than that in the pH-controlled one. The ethanol tolerance of XE-1 was higher than most xylose-fermenting, ethanol-producing microbes, but lower than Saccharomyces cerevisiae and Hansenula polymorpha. XE-1 showed tolerance to high concentration of xylose, and was able to grow and produce ethanol even when it was cultivated in 97.71 g/l xylose.

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Section: Discussionmentioning

confidence: 99%

Fermentation of xylose into ethanol by a new fungus strain Pestalotiopsis sp. XE-1

Pang

Liang

Huang

2010

J Ind Microbiol Biotechnol

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“…4-Oxo-4H-pyran-3-acetic acid (129) was isolated from the Chondracris rosea endophytic fungus Pestalotiopsis sp. HC02 (Zhang et al 2008). Pestalachlorides B (130) and C (131) are two chlorinated benzophenone derivatives found in the plant endophyte P. adusta.…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

“…HC02, a fungus residing in the gut of Chondracris rosea, along with 6-hydroxyramulosin (98). Among the above mentioned phytotoxins, compounds 96 and 97 notably inhibited radical growth of Echinochloa crusgalli with IC 50 values of 0.18 and 0.25 μM, respectively, and are thus comparable to 2-(2,4-dichlorophenoxy) acetic acid (IC 50 = 0.09 μM), which was used as a positive control (Zhang et al 2008). Chemical investigation of the endophyte Pestalotiopsis sp.…”

Section: Lactonesmentioning

confidence: 99%

Pestalotiopsis a highly creative genus: chemistry and bioactivity of secondary metabolites

2010

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Fungal endophytes are receiving increasing attention by natural product chemists due to their diverse and structurally unprecedented compounds which make them interesting candidates for drug discovery. One fungal genus which is especially productive with regard to the accumulation of a diverse array of mostly bioactive compounds is Pestalotiopsis. This review demonstrates the unique chemical diversity of taxa from this genus and describes their reported bioactivities. To date, alkaloids, terpenoids, isocoumarin derivatives, coumarins, chromones, quinones, semiquinones, peptides, xanthones, xanthone derivatives, phenols, phenolic acids, and lactones, have been reported from Pestalotiopsis species, making this genus a particularly rich source for bioprospecting when compared with other fungal genera. More than 130 different compounds that have been isolated from various species of Pestalotiopsis are covered in this review and their structures are reported within a biogenetic context. Bioassays disclosed that antifungal, antimicrobial, and antitumor activities are the most notable bioactivities of secondary metabolites isolated from this genus. Possible biogenetic pathways for monoterpenes, sesquiterpenes, quinones, and lactones that are covered in this review article are also illustrated.

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“…Considerable chemical investigations of this genus have led to the discovery of secondary metabolites, such as terpenoids and polyketides with antifungal and cytotoxic activity [2][3][4]. In connection with our ongoing search for structurally diverse secondary metabolites from plant endophytes [5][6][7][8], we investigated the chemical constituents of an endophytic fungus Pestalotiposis guepinii, leading to the isolation and characterization of one new diphenyl ether derivative pestalotilide A (1, Figure 1), along with four known pyrone derivatives LL-P880γ (2) [9], LL-P880α (3) [9], 10-hydroxy-4-methoxy-6-pentyl-2H-pyran-2-one (4) [9], and 2-(4-oxo-4H-pyran-3-yl)acetic acid (5) [10]. This paper deals with the isolation and structure elucidation of pestalotilide A, as well as its cytotoxicity.…”

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confidence: 99%

Pestalotilide A, a New Cytotoxic Diphenyl Ether Derivative from Pestalotiposis guepinii

Zhong

Lin

Zhao

et al. 2018

Natural Product Communications

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A new diphenyl ether derivative, named pestalotilide A (1), along with four known compounds (2-5) have been isolated from the organic extracts of an endophytic fungus Pestalotiposis guepinii. Their structures were elucidated on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic data analyses. These isolates were evaluated for cytotoxicity against three cancer cell lines: Hela, HCT116 and A549; pestalotilide A exhibited weak in vitro anti-proliferative activities against the tested cell lines, with IC50 values of 23.8, 18.4 and 35.2 μM, respectively.

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ChemInform Abstract: New Phytotoxic Metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee Gut.

Cited by 6 publications

References 13 publications

Fermentation of xylose into ethanol by a new fungus strain Pestalotiopsis sp. XE-1

Fermentation of xylose into ethanol by a new fungus strain Pestalotiopsis sp. XE-1

Pestalotiopsis a highly creative genus: chemistry and bioactivity of secondary metabolites

Pestalotilide A, a New Cytotoxic Diphenyl Ether Derivative from Pestalotiposis guepinii

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