Going with a gut reaction: Dalesconols A (structure shown) and B were discovered in the title fungus (middle picture) derived from the mantis gut. The novel architecture and biological profiles of these natural products make the dalesconols attractive lead compounds for the development of immunosuppressive agents.

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Heilkräftige Darmbewohner: Die Naturstoffe Dalesconol A (siehe Struktur rechts) und B wurden im Pilz Daldinia eschscholzii (Bild in der Mitte) gefunden, der aus dem Darm der Gottesanbeterin isoliert worden war. Ihre neuartigen Strukturen und biologischen Eigenschaften machen die Dalesconole zu vielversprechenden Leitverbindungen für die Entwicklung von Immunsuppressiva.

Two new phytotoxic gamma-lactones, pestalotines A and B (1 and 2, resp.), along with 4-oxo-4H-pyran-3-acetic acid (3) and 6-hydroxyramulosin (=3,4,4a,5,6,7-hexahydro-6,8-dihydroxy-3-methyl-1H-2-benzopyran-1-one; 4), were isolateded from the culture of Pestalotiopsis sp. HC02, a fungus residing in the Chondracris rosee gut. Structures of the new metabolites were elucidated on the basis of their IR, NMR, and MS data. Pestalotines A and B (1 and 2, resp.) significantly inhibited the radical growth of Echinochloa crusgalli with IC(50) values of 1.85 x 10(-4) and 2.50 x 10(-4) M, respectively, comparable to that of 2-(2,4-dichlorophenoxy)acetic acid (0.94 x 10(-4) M) used as a positive control.

Two new phytotoxic g-lactones, pestalotines A and B (1 and 2, resp.), along with 4-oxo-4H-pyran-3-acetic acid (3) and 6-hydroxyramulosin ( ¼ 3,4,4a,5,6,7-hexahydro-6,8-dihydroxy-3-methyl-1H-2-benzopyran-1-one; 4), were isolateded from the culture of Pestalotiopsis sp. HC02, a fungus residing in the Chondracris rosee gut. Structures of the new metabolites were elucidated on the basis of their IR, NMR, and MS data. Pestalotines A and B (1 and 2, resp.) significantly inhibited the radical growth of Echinochloa crusgalli with IC 50 values of 1.85 Â 10 À 4 and 2.50 Â 10 À 4 m, respectively, comparable to that of 2-(2,4-dichlorophenoxy)acetic acid (0.94 Â 10 À 4 m) used as a positive control.