ChemInform Abstract: New Pterosin Sesquiterpenes and Antitubercular Constituents from Pteris ensiformis.

Chen, Jih Jung; Wang, Tai‐Chi; Yang, Chieh‐Kai; Liao, Hsiang‐Ruei; Sung, Ping‐Jyun; Chen, Ih‐Sheng; Cheng, Ming‐Jen; Peng, Chien‐Fang; Chen, Jinn‐Fen

doi:10.1002/chin.201408212

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2019

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“…Pterosins can be classified into three categories according to the number of skeletal carbon, such as 13 carbon, 14 carbon and 15 carbon pterosin derivatives [6,7]. Pharmacological investigations showed that pterosins had many bioactivities, such as antitumor, anti-inflammatory, anti-diabetes and anti-tuberculosis properties [8,9,10,11]. However, most studies on pterosins from this genus focused on Pteris multifida [7].…”

Section: Introductionmentioning

confidence: 99%

Four New Pterosins from Pteris cretica and Their Cytotoxic Activities

Peng

Cheng

et al. 2019

Molecules

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Phytochemical investigation of the aerial parts of Pteris cretica led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (1), 13-hydroxy-2(R),3(R)-pterosin L (2), creticoside A (3), and spelosin 3-O-β-d-glucopyranoside (4), together with five known pterosins 5–9. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1 and 3 were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds 1 and 2 exhibited cytotoxic activity against HCT-116 cells with IC50 value of 22.4 μM and 15.8 μM, respectively.

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