ChemInform Abstract: Novel Synthetic Route to 1,4‐Dihydropyridines from β‐Amino Acrylates by Using Titanium(IV) Chloride under Facile Conditions.

Abstract

Novel Synthetic Route to 1,4-Dihydropyridines from β-Amino Acrylates by Using Titanium(IV) Chloride under Facile Conditions. -The cyclotrimerization of N-alkyl-or N-aryl-amino acrylates in the presence of substoichiometric amounts of TiCl4 affords dihydropyridines generally in high yields. The TFA-induced cyclization of amido acrylates such as (Va) as well as related secondary amines like (Vb) and (Vc) affords oxazolidinones. -(SIRIJINDALERT, T.; HANSUTHIRAKUL, K.; RASHATASAKHON, P.; SUKWATTANASINITT, M.; AJAVAKOM*, A.; Tetrahedron 66 (2010) 27-28, 5161-5167,