ChemInform Abstract: Phenacyl Esters of Acetic Acid Derivatives and Their Application for the Synthesis of 2‐Oxo‐4‐phenyl‐5‐(phenylhydrazono)‐2,5‐dihydrofuran‐3‐derivatives.

Abstract

The coupling of esters (III) with diazonium salts (IV) affords substituted oxofuranones (V) in moderate to good yields.Oxazolone and imidazolone analogues are obtained via similar methodologies. -(MELNICKY, R.; KVAPIL, L.; SLEZAR, P.; GREPL, M.; HLAVAC, J.; LYCKA, A.; HRADIL*, P.; J.

N-Methyl-phenacyloxycarbamidomethyl (Pocam) group: a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions

“…It has been demonstrated that a similar reaction was observed in phenacyloxycarbamide by heating without solvent. 10 Although various TFA cocktails were tested, this undesirable side reaction could not be suppressed, suggesting that the Poc group is not suitable for protecting the amino group of primary amines.…”

The Preparation of Various New Heterocyclic Compounds via Cyclization of Substituted Derivatives of Phenacyl Esters of Hydrazonoacetic Acid

“…Because the starting materials 3 are relatively complex and contain several reactive functional groups, the reactions and reaction conditions need to be carefully chosen. Phenacyl malonates react with diazonium salts to produce furan derivatives (Scheme 1); 9 thus, a different synthetic route had to be selected.…”