The coupling of esters (III) with diazonium salts (IV) affords substituted oxofuranones (V) in moderate to good yields.Oxazolone and imidazolone analogues are obtained via similar methodologies. -(MELNICKY, R.; KVAPIL, L.; SLEZAR, P.; GREPL, M.; HLAVAC, J.; LYCKA, A.; HRADIL*, P.; J.

No abstract

Coupling of various substituted phenacyl acetates 1 and diazonium salts 3 was studied. If the phenacyl acetates were substituted by an electronaceptor group such as CN or COOEt 3-substituted phenyl-5-(phenyl-hydrazono)-5H-furan-2-ones 4 were formed. Also synthesis of aza and diaza analogs is described. The compounds were characterized using MS and NMR spectroscopy.

A procedure for the preparation of derivatives of phen- acyl hydrazonopropanoates and their application in the synthesis of various heterocycles has been developed. Not only is the preparation of indole derivatives described, but also a new method for the preparation of previously unknown pyridazine derivatives

Benzopyran derivatives R 03503-Benzoyl-4-hydroxyisochromen-1-one Derivatives, Their Synthesis and Synthetic Application. -The title compounds (IV) are readily prepared by KOH-mediated cyclization of the phthalates (III). They serve as intermediates for the synthesis of various isocoumarin derivatives which are structurally related to anticancer active indenoisoquinolines. -(HRADIL*, P.; MELNICKY, R.; GREPL, M.; KORISTEK, K.; HLAVAC, J.; BERTOLASI, V.; Heterocycles 68 (2006) 9, 1845-1859; Dep. Org. Chem., Palacky Univ., CZ-771 46 Olomouc, Czech Republic; Eng.) -Mais 03-124