ChemInform Abstract: Pyrans: Heterocycles of Chemical and Biological Interest

Kumar, K. Ajay; Renuka, N.; Archana, G.; Lokeshwari, D. M.

doi:10.1002/chin.201633238

Cited by 10 publications

(11 citation statements)

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“…Six-membered heterocycles such as pyrans were considered as versatile substrates in the field of bioorganic chemistry [5,6]. Fused pyran derivatives represent an important class of compounds which possess high activity profile due to their wide range of biological activities [7].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

Gurunanjappa

Ningappa

Kariyappa

2016

Chemical Data Collections

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Section: Accepted Manuscriptmentioning

confidence: 99%

Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

Gurunanjappa

Ningappa

Kariyappa

2016

Chemical Data Collections

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“…Как известно из литературы, замещенные пираны проявляют противоопухолевое, антибактериальное, противовоспалительное действие, противоотечные, спазмолитические, противогрибковые и противовоспалительные свойства [4][5][6][7][8][9][10][11]. ***…”

Section: R = 4-n(ch 3 ) 2 2-och 3 3-och 3 R 1 = Ch 3 4-c 2 H 5 unclassified

Reactions of 2-arylidenemalononitriles with dilute nitric acid and methyl 2,4-dioxobutanoate

Sheverdov¹,

Timofeeva²,

Иванова³

et al. 2019

Тенденции Развития Науки И Образования

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Изучена реакционная способность 2-арилиденмалононитрилов по отношению к разбавленной азотной кислоте и метил 2,4-диоксобутаноатам. Разработаны методы синтеза 2-циано-3-арилакриловых кислот, 3-ацил-6-амино-5-циано-4-арил-4H-пиран-2карбоксилатов. Установлено, что при действии на 2-(4-(диметиламино)бензилиден)малононитрил разбавленной азотной кислотой образуется 2-(4-(диметиламино)-3,5-динитробензилиден)малононитрил. Ключевые слова: 2-арилиденмалононитрилы, гидролиз, метил 2,4диоксобутаноаты, 2-циано-3-арилакриловые кислоты, пираны.

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“…Pyran is also one of the important structural subunits found widely in natural products, e.g. coumarins, benzopyrans, sugars, flavonoids, xanthones, etc [15][16][17]. There are also some publications have reported that the combination of isatin and pyran nucleus could be a worthy choice for anticancer activity against various human tumor cell lines [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Faghih

Divar

et al. 2019

JPRI

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Aims: Isatin is a honored scaffold and one of the most favorable class of heterocyclic systems that possesses many interesting biological activities and well-tolerated in humans. Here a series of fifteen spirooxindole-4H-pyran derivatives containing both isatin and pyran moieties (ICa-ICo) will be examine for their anti-cancer activity. Study Design: Cytotoxic evaluation of some spirooxindole-4H-pyran derivatives in two cancerous cell lines. Place and Duration of Study: Pharmaceutical Science Research Center and Shiraz Institute for Cancer Research, Medical School in Shiraz University of Medical Sciences, Shiraz, Iran, between June 2018 and July 2019. Methodology: MTT assay was used to evaluate the cytotoxic activities of these compounds. The anticancer properties of the tested compounds were determined using A549 and MCF-7 cell lines. Results: Among the tested compounds ICc, ICd and ICf showed the best cytotoxic activities against both cancerous cell lines. Compounds ICh and ICj showed desirable cytotoxic activities against A549 cell line. Compound ICb showed desirable cytotoxic activities against MCF-7 cell line. Conclusion: We conclude that the isatin-linked pyran analog can serve as a prototype molecule for further development of a new class of anticancer agents.

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ChemInform Abstract: Pyrans: Heterocycles of Chemical and Biological Interest

Cited by 10 publications

References 0 publications

Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

Reactions of 2-arylidenemalononitriles with dilute nitric acid and methyl 2,4-dioxobutanoate

Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

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