ChemInform Abstract: Reduction and Reductive Preparation of Deuterated Compounds Using Raney Ni—Al Alloy

Ishimoto, Keiko; Mitoma, Yoshiharu; Kanda, Tadashige; Suzuki, Hiroshi; Matsuda, Toshio; Tashiro, Masashi

doi:10.1002/chin.200221265

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2022

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“…The alloy exhibited high activity in an alkaline medium. For instance, various benzaldehydes, anilines and benzylamines were successfully deuterated with the Ni/Al alloy-Na 2 CO 3 -D 2 O system [ 26 , 27 ]. The amino acids tyrosine and phenylalanine were also subjected to this highly active catalytic system [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions

2022

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The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, notably their use as improved drug candidates and biological probes, the efficient and selective deuteration methods are of great interest. The approach is based on selective H-D exchange reactions where the deuterium source is simple D2O. D2 gas is generated in situ from the reaction of aluminum and D2O, while the commercially available palladium catalyst assists the H-D exchange reaction. The high selectivity and efficiency, as well as the simplicity and safe nature of the procedure make this method an environmentally benign alternative to current alternatives.

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Section: Introductionmentioning

confidence: 99%