ChemInform Abstract: Solid Dispersion: A New Horizen in Novel Drug Delivery System

Rathore, Devender Singh; Thakur, Reeta Rani; Narwal, Sonia

doi:10.1002/chin.201327240

Cited by 2 publications

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“…The final solid mass is then crushed to reduce the particle size to be incorporated homogeneously in a suitable dosage form. 39 The melting point of this binary system depends on its composition, carrier selection and the weight fraction of the drug in the system. For example, poloxamer (P 188 ) has a low melting point making it a suitable candidate for the fusion method.…”

Section: Hot-melt Methods (Fusion-based Method)mentioning

confidence: 99%

Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs

Attia¹,

Hasan²,

Ghazy³

et al. 2021

IJPER

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Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve the solubility of slowly dissolving drugs. A variety of pharmaceutically compatible additives using different emerging technology is used for preparing SDs. Multiple approaches were designed to prepare SDs by such as kneading, co-milling, fusion, solvent evaporation and various solvent-associated methods. The selection of appropriate preparation method and carrier is vital for producing a homogenous product affecting its stability and biological activity. Many attempts were recently carried out to improve the scalability of the applied approaches and the results were novel preparation methods such as KinetiSol, Electrospinning and Hot-melt extrusion. In the present review, drug carriers used to formulate SD were classified as small molecular weight carriers, large molecular weight named polymeric carriers and functionalized polymeric ones. Moreover, new attractive SD formulated using the newly emerged natural carriers recently joined the field of the pharmaceutical industry.

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Section: Hot-melt Methods (Fusion-based Method)mentioning

confidence: 99%

Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs

Attia¹,

Hasan²,

Ghazy³

et al. 2021

IJPER

View full text Add to dashboard Cite

show abstract

“…A number of insoluble drugs has shown to improve their dissolution character when converted to solid dispersion. Solid dispersion is used to produce a homogeneous distribution of a small amount of drug in solid state 3 .…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Solubility and Dissoultion Rate of Domperidone Using Cogrinding and Kneading Technique

Tyagi

Dhillon

2012

J. Drug Delivery Ther.

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Improving the solubility and dissolution rate of domperidone using PEG 4000 and PVP K25 as a carriers in combination by Solid Dispersion Technique. Methods: Solid dispersions of domperidone were prepared using different ratios of PVP and PEG as carrier by co grinding and kneading method. The co grinding mixtures were prepared by mixing appropriate amounts of drug and carriers in different mass ratio in mortar and pestle. In kneading method, minimum quantity of water-ethanol mixture was used for dispersion of drug and carriers. The prepared solid dispersions were characterized for their drug content, invitro dissolution studies, FTIR spectroscopy and DSC were performed to identify physiochemical interaction between the drug and carrier and its effect on dissolution behavior. A comparative evaluation of the dissolution profiles of domperidone solid dispersion tablets and marketed formulation (tablet) was carried out. Results: The prepared formulations showed marked improvement in the solubility and dissolution rate of drug which may be due to decrease in crystallinity of drug and additives. Formulation (S2) 1:2:2 of DOM :PEG:PVP gives fast dissolution rate 85.77% of drug as compared to others formulation and marketed product (M P) in 1hr. Conclusion: The prepared solid dispersion of the Domperidone with PEG and PVP can improve the solubility and dissolution rate of the drug.

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ChemInform Abstract: Solid Dispersion: A New Horizen in Novel Drug Delivery System

Abstract: Review: 67 refs.

Cited by 2 publications

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Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs

Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly Water-Soluble Drugs

Enhancement of Solubility and Dissoultion Rate of Domperidone Using Cogrinding and Kneading Technique

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