ChemInform Abstract: Studies on Synthesis and Antitubercular Activity of Some (±)‐α‐Aceto‐N,N′‐diaryl‐succinamides.

Dave, M. P.; Patel, J. M.; Langalia, N. A.; Shah, Shailesh R.; Thaker, K. A.

doi:10.1002/chin.198612196

Cited by 3 publications

(3 citation statements)

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“…-Lactide was stored at 4°C as supplied, to avoid the formation of lactyl lactate. N-Phenyl chloroacetamide [62] and 1-isopropylimidazole [63] were synthesized according to literature procedures.…”

Section: Methodsmentioning

confidence: 99%

A Cationic (N‐Heterocyclic carbene)silver Complex as Catalyst for Bulk Ring‐Opening Polymerization ofL‐Lactides

et al. 2006

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Synthetic, theoretical, and catalysis studies of a cationic functionalized N-heterocyclic carbene complex of silver, namely, is reported. Specifically, 1b was synthesized by the reaction of 1-isopropyl-3-(N-phenylacetamido)imidazolium chloride (1a) with Ag 2 O in 64 % yield; 1a was synthesized by the alkylation reaction of 1-isopropylimidazole with N-phenyl chloroacetamide in 90 % yield. The molecular structure of 1b was determined by X-ray diffraction studies and was found to be active for polymerization of L-lactide at elevated temperatures under solvent-free melt conditions to give polylactide of moderate molecular weight with narrow molecular weight distribution. Density functional theory studies of the cationic species 2b, derived from NHC silver complex 1b, were employed to obtain an understanding of the structure, bonding, and electronic features of the mole-

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Section: Methodsmentioning

confidence: 99%

A Cationic (N‐Heterocyclic carbene)silver Complex as Catalyst for Bulk Ring‐Opening Polymerization ofL‐Lactides

et al. 2006

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“…17). In addition to the above, other classes of molecules that have been evaluated for their antitubercular activities comprise 4-(coumarinyl)-4-thiozolin-2-one-benzylidene-hydrazones, 247 3-hydrazono-1 H-2-indolinones, 248 quinoxaline-1, 4-di-N-oxides, 249 cyclohexadiene 250 N-(2-naphthyl) glycin hydrazide analogous, 251 isoxazoles and cynopyridines, 252 4-phenyl-1, 8-naphthyridine, 253 aminolupinanes, 254 benzoyl thiozole-2-carbamates, 255 thiosemicarbazones, 256 dithiocarbamates, 257 thiazolidinones, [258][259][260] succinamides, 261 diarylsuccinamides, 262 glutaconyl-thiosemicarbazides, 263 2,2 0 -dithio-bis (benzamides), 264 1,3,5-triazines, 265 trimethyl silyl-3-(carbethoxy carbamoyl) propionates 266 pyrrolnitrin and pyrrole derivatives [267][268][269][270] diguanidino and ''reversed'' diamidino 2,5-diaryl-furans, 271 1,2,4 triazoles, 272,273 thiazole, 274 1,3,5 thiadiazole, 275 quinazolines, 276 quinolines, 277 3-Me-N 0 (disubstituted-quinolinyl) pyrazol-5-ones 278 quinoxaline 1,4 dioxides, 279 quinoxaline-2-carboxamide 1,4-di-N-oxide, 280 nitroquinolones, 281 2,4-dihydroxy quinolines 282 3nitro-and 3-bromo-4-hydroxy-2 quinooines, 283 quinazolinones, 284 6-nitro quinazolones, 285 benzimidazole, 286 benzazole 287 substituted 2-(4-amino phenyl sulphonamido)-benzothiazoles, 288 3-aryl substit...…”

Section: K Marine Natural Productsmentioning

confidence: 99%

Fighting tuberculosis: An old disease with new challenges

et al. 2005

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Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a leading cause of mortality worldwide into 21st century. The mortality and spread of this disease has further been aggravated because of synergy of this disease with HIV. A number of anti-TB drugs are ineffective against this disease because of development of resistance strains. Internationally efforts are being made to develop new anti-tubercular agents. A number of drug targets from cell wall biosynthesis, nucleic acid biosynthesis, and many other biosynthetic pathways are being unraveled throughout the world and are being utilized for drug development. In this review, socioeconomic problems in developing countries, efforts to control this disease in different individuals, the targets (known already and newly discovered), existing anti-tubercular agents including natural products and lead molecules, and the future prospects to develop new anti-TB agents are described.

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“…Other authors have described various kinds of biological activity of alkanediamide derivatives as well. For example, some 2-methylcarbonylbutanediamides are active against M. tuberculosis [2], 2,3-diarylpentanediamides display activity against Gram-positive bacteria [3], and N,N'-substituted 2-halobutanediamides act as herbicides [4]. Raynes et al studied the influence of the length of the connecting chain on the antimalarial activity of bisquinolines; the derivative of butanediamide was the most efficient [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity

et al. 2000

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A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane-and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.

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ChemInform Abstract: Studies on Synthesis and Antitubercular Activity of Some (±)‐α‐Aceto‐N,N′‐diaryl‐succinamides.

Abstract: Die aus Acetessigsäureethylester (I) und den primären Arylaminen (II) erhaltenen Acetessigsäurearylamide (III) lassen sich mit Chloracetamiden (IV) zu den Acetylbernsteinsäure‐bis‐amiden (V) alkylieren.

Cited by 3 publications

References 0 publications

A Cationic (N‐Heterocyclic carbene)silver Complex as Catalyst for Bulk Ring‐Opening Polymerization ofL‐Lactides

A Cationic (N‐Heterocyclic carbene)silver Complex as Catalyst for Bulk Ring‐Opening Polymerization ofL‐Lactides

Fighting tuberculosis: An old disease with new challenges

Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity

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