ChemInform Abstract: Syntheses and Cardiovascular Activity of Stereoisomers and Derivatives of Eburnane Alkaloids.

Czibula, László; Nemes, András; Visky, György; M, Farkas; Szombathelyi, Zsolt; Kárpáti, E; Sohar, P.; Kessel, Martin; Kreidl, J.

doi:10.1002/chin.199326227

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(-)-20-epi-vincamine and (-)-20-epi-eburnamonine1

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2021

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“…28 Although (+)-vincamine and (−)eburnamonine display a wide variety of pharmacological activities, the non-natural epimers of these natural products have been demonstrated to be far more potent, particularly in peripheral vasodilation. 29 The major difficulty in…”

Section: (-)-20-epi-vincamine and (-)-20-epi-eburnamoninementioning

confidence: 99%

Recognition of Symmetry as a Powerful Tool in Natural Product Synthesis

et al. 2021

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The design of concise and efficient synthetic strategies to access naturally occurring, pharmaceutically active complex molecules is of utmost importance in current chemistry. It not only enables rapid access to these molecules and their analogues but also provides sufficient quantities for their biological evaluation. Identification of any symmetric or pseudosymmetric synthetic intermediates upon retrosynthetic bond disconnection of the target molecule holds the promise to significantly streamline the route towards the compound of interest. This review will highlight recent examples of successful natural product syntheses reported within the past five years that benefited from the recognition of symmetry elements during the retrosynthetic design.

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Section: (-)-20-epi-vincamine and (-)-20-epi-eburnamoninementioning

confidence: 99%