ChemInform Abstract: Synthesis and Antitubercular Activity of Benzothieno(2,3‐d)pyrimidine Derivatives.

Abstract

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Molecular Construction Using Formamide as a C1 Feedstock

“…These structures can also be prepared using formamide and different enamines, and the −NH 2 group can cyclize with amides or esters to afford pyrimidones (Schemes 5 and 6). In 1991, Kapustina [14a] synthesized new quinolinones by boiling carboxilic acid in formamide. In 1995, Nandeeshaiah and Ambekar [14b] synthesized pyrimidones fused to selenophene and pyrimidine nuclei by refluxing the starting material with excess formamide, yielding 65–70 % after 2–3 h of reaction.…”