ChemInform Abstract: Synthesis and Biological Activities of Pyrimidines: A Review

Merugu, Ramchander; Garimella, Swetha; Balla, Deepthi; Kalyani, S

doi:10.1002/chin.201629252

Cited by 14 publications

(12 citation statements)

References 3 publications

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“…Finally, all derivatives in this series can be considered outstanding multitarget inhibitors for further AD treatment investigations. Anhydrous K 2 CO 3 (2 eq) was added to a mixture of 3-iodo-1H-pyrazolo [3,4-d]pyrimidin-4-amine (1 eq) and alkyl halide (3,9,11,13,15) (2 eq) in dry DMF (50 ml). The reaction mixture was stirred overnight at 70°C under a nitrogen atmosphere.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Aydın

Anıl

Demir

2021

Archiv der Pharmazie

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Fused pyrimidines, especially pyrazolo [3,4-d]pyrimidines, are among the most preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of biological activity. In this study, new derivatives of pyrazolo [3,4-d]pyrimidine were synthesized by alkylation of the N1 nitrogen atom. We synthesized 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine 2 from commercially available aminopyrazolopyrimidine 1 using N-iodosuccinimide as an iodinating agent. The synthesis of compound 2 started with nucleophilic substitution of 3-iodo-1H-pyrazolo [3,4-d]pyrimidin-4-amine with R-X (X:-OMs, -Br, -Cl), affording N-alkylated pyrazolo [3,4-d]pyrimidine. We performed this synthesis using a weak inorganic base and the mild temperature was also used for a two-step procedure to generate N-alkylated pyrazolo [3,4-d]pyrimidine derivatives. Also, all compounds were tested for their ability to inhibit acetylcholinesterase (AChE) and the human carbonic anhydrase (hCA) isoforms I and II, with K i values in the range of

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Section: Discussionmentioning

confidence: 99%

Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Aydın

Anıl

Demir

2021

Archiv der Pharmazie

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“…Most of these building blocks are vital compounds found in structures of the human body, such as pyrimidines in DNA structures or amino acids in proteins. [ 4–7 ] Introduction of pyrrole by Hantzsch in 1890, [ 8 ] pyrimidone by Biginelli in 1891, [ 9 ] pyridine by Chichibabin in 1906, [ 10 ] α‐acyloxycarboxamide by Passerini in 1921, [ 11 ] coupling of aryl halides with amines by Buchwald in 1994, [ 12 ] and Ullmann‐type coupling reactions [ 13 ] are some of examples in this context. Although they used different strategies, classification of these reactions as coupling and multicomponent reactions (MCRs) is common way to study these methods.…”

Section: Introductionmentioning

confidence: 99%

Carbon–nitrogen bond formation using modified graphene oxide derivatives decorated with copper complexes and nanoparticles

Mirza‐Aghayan

Saeedi

Boukherroub

2021

Applied Organom Chemis

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Several catalytic reactions such as Ullmann, Chan–Lam, Huisgen 1,3‐dipolar cycloaddition, [2 + 3] cycloaddition, condensation, and coupling reactions under suitable conditions have been used for the synthesis of fundamental structures containing a carbon–nitrogen (C–N) bond. Graphene oxide (GO) and its derivatives as heterogeneous catalysts have attracted considerable attention for the synthesis of organic building blocks. Loading of GO derivatives with copper complexes or nanoparticles, as one of the most abundant and low toxic transition metals, allowed to design new composites with predominant ability to C–N bond formation. In this review article, we present a comprehensive overview on the synthesis of building blocks containing a C–N bond such as amines, triazoles, tetrazoles, propargyl amines, imidazoles, and benzodiazepines using GO derivatives loaded with copper complexes or nanoparticles.

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“…Pyrimidine moiety is also found in various biologically active synthetic compounds, such as, HIV drug zidovudine [1]. As pyrimidine is a basic nucleus in DNA & RNA, it has been found to be associated with diverse biological activities and its derivatives have attracted much attention due to their remarkable and prominent pharmacological activity [2].…”

Section: Introductionmentioning

confidence: 99%

Cyanoacetyl urea in heterocyclic synthesis part V: Facile synthesis of poly-functionalized pyrimdines via different behaviors of its free urea amino group

2018

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ChemInform Abstract: Synthesis and Biological Activities of Pyrimidines: A Review

Abstract: Review: 50 refs.

Cited by 14 publications

References 3 publications

Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

Carbon–nitrogen bond formation using modified graphene oxide derivatives decorated with copper complexes and nanoparticles

Cyanoacetyl urea in heterocyclic synthesis part V: Facile synthesis of poly-functionalized pyrimdines via different behaviors of its free urea amino group

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