Cyanoacetyl urea in heterocyclic synthesis part V: Facile synthesis of poly-functionalized pyrimdines via different behaviors of its free urea amino group

Abstract

T HE poly-functional precursor, cyano-acetyl urea, could be utilized in the synthesis of various pyrimidens utilizing its benzothiazole derivative 1. The free amino group in 1 undergoes different chemical behavior according to the reaction conditions to afford pyrimidines 3

A review on synthesis of nitrogen-containing heterocyclic dyes for textile fibers - Part 2: Fused heterocycles

“…Dyes have been used as natural and synthetic products for a variety of applications, such as inkjet printing, plastics, textile coloration, adhesives, beverages, ceramics, photography, cosmetics, foodstuff, optoelectronics, coatings, sensors, xerography, constructions and biomedical applications [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Heteroaromatic compounds have been used in various fields of life sciences and technology [15][16][17][18][19][20][21]. Numerous of heterocyclic dyes are now commercialized to produce a full range of dyestuffs especially for textile coloration.…”

Sharing via Low-Cost Discovery in Global Effort for Combat Diseases: Simple Chemical Routes for Lead Compounds Using Biomass Driven Building Blocks.

“…as polyfunctional compounds, we directed our work utilizing some of them to synthesize new heterocyclic compounds. Acetylated glycine, for example, was utilized via a simple route for the synthesis of various heterocyclic compounds [36][37][38]. Following this route, reaction of cyanoacetyl glycine 40 with different aldehydes resulted in the synthesis of new series of ylidines which are active precursors for the new compounds 42 and 43 that exhibit potent antitumor activity [14].…”

Antibacterial Azo Dyes Containing Sulfa Drug Moieties and Their Colour Assessment on Printing Polyester Fabric

“…As part of our program focused on the synthesis of new biologically active molecules, we previously reported on the use of new cyanoacetyl derivatives in a wide range of biologically active heterocyclic compounds. [16][17][18][19][20][21] Recently, the synthesis of new dyes by combining sulfa derivatives, which are known to have antibacterial properties [3] with a nontoxic antibacterial cyanoacetyl microcrystalline cellulose derivative, was reported. [22][23] In the present study, conjugates were synthesized by bridging cyanoacetyl urea utilizing its active methylene as C-Nucleophile and benzothiazol-2-ylacetohydrazide utilizing its active hydrazino N-Nucleophile to with aryl/aryl sulfonamide via an azo linker.…”

“…As part of our program focused on the synthesis of new biologically active molecules, we previously reported on the use of new cyanoacetyl derivatives in a wide range of biologically active heterocyclic compounds [16–21] . Recently, the synthesis of new dyes by combining sulfa derivatives, which are known to have antibacterial properties [3] with a nontoxic antibacterial cyanoacetyl microcrystalline cellulose derivative, was reported [22–23] …”