ChemInform Abstract: SYNTHESIS AND INVESTIGATION OF THE BARBITURIC ACID DERIVATIVES

Pilyugin, G. T.; Prisyazhnyuk, P. V.; Палий, Г. К.; Opanasenko, E. P.; Volyanskii, Yu. L.

doi:10.1002/chin.197548331

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Experimental Chemical Part1

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2011

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“…N-Phenyl-5,6-benzoquinaldinium salts were synthesized by a modified literature method [12] via cyclization of phenyl-b-naphthylamine (I) and paraldehyde (Scheme). N-Phenyl-5,6-benzoquinaldinium iodide (VIII).…”

Section: Experimental Chemical Partmentioning

confidence: 99%

Synthesis and antimicrobial activity of quaternary N-aryl-5,6-benzoquinaldinium derivatives

Щепина

Boiko²,

Александрова

2011

Pharm Chem J

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A series of quaternary N-aryl-5,6-benzoquinaldinium derivatives have been synthesized. Their antimicrobial activity (E. coli, S. aureus) has been tested. It was found that introduction of a new annelated benzene ring into the heterocyclic molecule (compared with quinolinium and benzoquinolinium compounds) leads to a significant increase of the antibacterial activity. Electron-withdrawing substituents in the quaternary phenyl group decrease slightly the antimicrobial effect. Since better results have been obtained for N-phenyl-5,6-benzoquinaldinium tetrafluoroborate, biological investigations were continued on the additional test cultures S. saprophyticus, Salmonella spp., Micrococcus luteus, Proteus vulgaris, Bacillus subtilis, and Candida albicans. The observation of high fungicidal activity against C. albicans was promising.

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Section: Experimental Chemical Partmentioning

confidence: 99%

Synthesis and antimicrobial activity of quaternary N-aryl-5,6-benzoquinaldinium derivatives

Щепина

Boiko²,

Александрова

2011

Pharm Chem J

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ChemInform Abstract: SYNTHESIS AND INVESTIGATION OF THE BARBITURIC ACID DERIVATIVES

Abstract: Umsetzung der Salze der Chinaldine (I) mit 1‐Methyl‐ und 1,3‐Dimethyl‐alloxan (II) führt zu den Kondensationsprodukten (III).

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Synthesis and antimicrobial activity of quaternary N-aryl-5,6-benzoquinaldinium derivatives

Synthesis and antimicrobial activity of quaternary N-aryl-5,6-benzoquinaldinium derivatives

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