ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF 2‐HYDROXYINDAN‐1,3‐DIONE DERIVATIVES. I. COMPOUNDS OF CONDENSATION OF NINHYDRIN WITH C‐ALKYLPHENOLS

Abstract

Ninhydrin kondensiert beim Erhitzen mit äquimolekularen Mengen C‐alkylierter Phenole in Eisessig zu monosubstituierten Derivaten des Typs (I) bzw. (II).

Synthesis and Fluorescent Properties of a New Class of Heterocycles of Isoindole Fused Imidazoles with Phenolic Subunits

“…When phenols 1a − m are refluxed in a mixture of ninhydrin and acetic acid, 2-hydroxy-2-(2‘-hydroxy-aryl)-1,3-indanediones 2a − m are formed (Scheme ) . The adducts so formed preferentially remain in the cyclic hemiketal form 3a − m . 9a-c Interestingly refluxing of 3 with urea in the same acetic acid mixture produces 1-aryl-3,5- dioxo-1 H -imidazo-[3,4- b ]isoindole 4a − m by condensation reaction (Scheme , Table ) . The isolated pure compounds 4a − m are yellow solids.…”