ChemInform Abstract: Synthesis and Pharmacological Properties of 1‐R‐3‐(3‐R′‐Amino‐2‐hydroxypropyl)‐1,2,3,4‐tetrahydro‐β‐carboline Dihydrochlorides.

Abstract

215ChemInform Abstract The carbolines (I) react with epichlorohydrin (II) to form the 2-glycidylcarbolines (III) which are treated with the primary amines (IV), producing the title compounds (V). The compounds (V) have weak psychotropic, α-and β-adrenolytic, and sympatholytic activity.