ChemInform Abstract: Synthesis and Radioprotective Activity of Functionally Substituted Methyl Alkyl Sulfoxides.

Abstract

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(2E,6E)‐2,6‐Bis(organylchalogenylmethylidene) substituted 1,4‐dithiane 1,1,4,4‐tetraoxides and N‐organyl thiomorpholine 1‐oxides as new S‐oxide derivatives of bis(2‐organylchalcogenylvinyl) sulfides

“…It is worthwhile to note that S ‐oxides of 1,4‐dithiane and thiomorpholines are important building blocks in medicinal chemistry, and some analogs containing these moieties have passed human clinical trials. So, among derivatives of 1,4‐dithiane 1‐oxide, a compound with pronounced antiradiation activity against gamma rays is found . Thiomorpholine 1‐oxide moieties are met in the structures of the compounds that are applied for the treatment of autoimmune and inflammatory diseases, cardiovascular and tumor diseases, ischemic cerebral disorders, cancer .…”