ChemInform Abstract: SYNTHESIS AND RADIOPROTECTIVE ACTIVITY OF GERMA‐ AND SILATHIAZOLIDINES

Abstract

Die Titelverbindungen (I) wurden durch Reaktion stöchiometrischer Mengen von Cysteamin oder Methylcysteamin mit Ge‐ bzw. Si‐chloriden in Gegenwart von NEt3 oder mit Dimethylaminogermanen oder ‐silanen in THF dargestellt.

Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N‐substituted Naphthylethylimidazoline

“…Method A The action of the dichlorodiorganometallane [22] [22][23][24][25][26] The action of dichlorodihexylgermane, in stoichiometric amounts, on 1,3-bis(trimethylsilyl)selenourea, in refluxing anhydrous tetrahydrofuran in the presence of freshly distilled triethylamine gave by a cyclization reaction, with elimination of hydrochloric acid from Ge-C1 and NH [22,26] …”

Synthesis and application of new organometallic compounds of silicon and germanium in chemical radioprotection

“…IR spectra were recorded on a Perkin-Elmer 1600 FT-IR spectrophotometer. 1 H NMR spectra were recorded on a Bruker AC 80 (80.13 MHz) and 13 C NMR spectra were recorded on a Bruker AC 200 (50.32 MHz) spectrometer; the multiplicity of the 13 C NMR signals was determined by the APT technique and quoted (À) for CH 3 and CH, () for CH 2 and (C quat ) for quaternary carbon atoms. Mass spectra under electron impact (EI) conditions at 70 and 30 eV were recorded on a Hewlett-Packard 5989A …”

“…1,[12][13][14][15] The reaction of 18 and 19, in stoichiometric amounts, with the bis(diethylamino)dialkylmetallanes in anhydrous toluene resulted in cleavage of M-N bonds (M = Si, Ge) by the NH and SH groups, forming the corresponding metallathiazolidines in good yields (Scheme 2).…”

“…[1][2][3][4][5][6][7][8][9][10][11] This report concerns the synthesis and evaluation in chemical radioprotection of new organosilylated and organogermylated structures, which have been prepared by the condensation of bis(diethylamino)dialkylmetallanes with derivatives 18 or 19. In this work, we present the study of the toxicity and radioprotective activity of metallathiazolidines and metalladithioacetals (Scheme 1).…”

Nouveaux phosphorothioates dérivés de la naphthylméthylimidazoline et de la naphthyléthylimidazoline : application en radioprotection chimique

“…Article published by EDP Sciences and available at http://www.edpsciences.org/radiopro or http://dx.doi.org/10.1051/radiopro:2004016 développés par notre laboratoire (Célariès et al, 2001a(Célariès et al, , 2001b(Célariès et al, , 2003a(Célariès et al, , 2003bFatôme et al, 1984Fatôme et al, , 1988Rima et al, 1991Rima et al, , 1993Rima et al, , 1994Rima et al, , 1996Rima et al, , 1997Rima et al, , 1998Rima et al, , 1999aRima et al, , 1999bSatgé et al, 1982Satgé et al, , 1989, à savoir : -la libération in vivo, retardée ou prolongée, d'une ou plusieurs substances organiques possédant des propriétés radio-protectrices (aminothiols) ; -une modification fondamentale des propriétés chimiques ou biologiques de ces dérivés de base.…”