Synthesis and application of new organometallic compounds of silicon and germanium in chemical radioprotection

Rima, G.; Satgé, J.; Dagiral, Rodolphe; Lion, Claude; Fatome, M.; Roman, V. K.; Laval, J. D.

doi:10.1002/(sici)1099-0739(199908)13:8<583::aid-aoc892>3.0.co;2-d

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…Synthesis of selenagermaadamantane 15 The treatment of isoamyltrichlorogermane with lithium selenide gave tetragermahexaselenide 15 [27]. (Scheme 7).…”

Section: Molecular Modelisation Study (Essf Field)mentioning

confidence: 99%

Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N‐substituted Naphthylethylimidazoline

Célariès

Rima

Court³

et al. 2001

Metal-Based Drugs

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A number of organosilicon and organogermanium derivatives and some related compounds including the N -substituted. 2-[1-naphthylmethyl]-2-imidazoline and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and the toxicity of some compounds have been determined in mice. In this paper we report the synthesis and the evaluation of the pharmacological activity of new organosilicon and organogermanium, compounds such as sila- and germadithioacetals derived from N -substituted naphthylimidazolne.

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“…Synthesis of selenagermaadamantane 15 The treatment of isoamyltrichlorogermane with lithium selenide gave tetragermahexaselenide 15 [27]. (Scheme 7).…”

Section: Molecular Modelisation Study (Essf Field)mentioning

confidence: 99%

Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N‐substituted Naphthylethylimidazoline

Célariès

Rima

Court³

et al. 2001

Metal-Based Drugs

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“…Article published by EDP Sciences and available at http://www.edpsciences.org/radiopro or http://dx.doi.org/10.1051/radiopro:2004016 développés par notre laboratoire (Célariès et al, 2001a(Célariès et al, , 2001b(Célariès et al, , 2003a(Célariès et al, , 2003bFatôme et al, 1984Fatôme et al, , 1988Rima et al, 1991Rima et al, , 1993Rima et al, , 1994Rima et al, , 1996Rima et al, , 1997Rima et al, , 1998Rima et al, , 1999aRima et al, , 1999bSatgé et al, 1982Satgé et al, , 1989, à savoir : -la libération in vivo, retardée ou prolongée, d'une ou plusieurs substances organiques possédant des propriétés radio-protectrices (aminothiols) ; -une modification fondamentale des propriétés chimiques ou biologiques de ces dérivés de base.…”

Section: Introductionunclassified

Nouveaux phosphorothioates dérivés de la naphthylméthylimidazoline et de la naphthyléthylimidazoline : application en radioprotection chimique

et al. 2005

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RÉSUMÉDans ce travail, nous avons synthétisé des phosphorothioates dérivés de la 2-(1-naphthylméthyl)-2-imidazoline et de la 2-[1-(1-naphthyl)éthyl]-2-imidazoline afin d'évaluer, in vivo chez la souris, leur degré de protection contre les effets des rayonnements γ. Tous ces composés ont montré une activité radioprotectrice remarquable (facteur de réduction de dose compris entre 1,5 et 1,9) ce qui les classent parmi les plus actifs actuellement connus dans le domaine de la radioprotection chimique. Ces composés peuvent également présenter un intérêt dans le domaine des traitements de chimio-et de radio-thérapie.ABSTRACT New phosphorothioates derived from naphthylmethylimidazoline and naphthylethylimidazoline: application in chemical radioprotection.In this work, we report the radiopharmacological study (radioprotective activity, toxicity) of new phosphorothioates derived from 2-(1-naphthylmethyl)-2-imidazoline and 2-[1-(1-naphthyl)ethyl]-2-imidazoline. The radioprotective efficacy against γ-rays of these organophosphorus compounds was evaluated in vivo. All these derivatives have shown a dose reduction factor between 1.5 and 1.9 which traduce their excellent radioprotective activity. These compounds should present an interest in the chimio-and radiotherapy treatments.

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Radioprotective activity of metalladithioacetals derived from N‐substituted naphthylethylimidazoline

Célariès

Amourette

Lion

et al. 2003

Applied Organom Chemis

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Synthesis and application of new organometallic compounds of silicon and germanium in chemical radioprotection

Cited by 10 publications

References 26 publications

Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N‐substituted Naphthylethylimidazoline

Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N‐substituted Naphthylethylimidazoline

Nouveaux phosphorothioates dérivés de la naphthylméthylimidazoline et de la naphthyléthylimidazoline : application en radioprotection chimique

Radioprotective activity of metalladithioacetals derived from N‐substituted naphthylethylimidazoline

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