ChemInform Abstract: Synthesis of New Pyrroles of Potential Antiinflammatory Activity.

Abstract

Novel pyrrole derivatives and pyrrolo[2,3‐d]pyrimidine derivatives are synthesized and some of them are tested for their in vivo antiinflammatory activity.

A facile synthesis of 1-aryl pyrroles by Clauson-Kaas reaction using oxone as a Catalyst under microwave irradiation

“…Many of these compounds have drawn the attention in various fields like natural product synthesis, functional materials, ligands, biological and pharmacological activities [1][2][3][4][5][6]. Among nitrogen containing five-member heterocycles, pyrrole is one of the modest class of heterocyclic compounds possessing wide range of biological activities, such as antimicrobial [7][8], antiviral [9], antitumor [10], anti-inflammatory [11] and antioxidant [12]. In addition, there is a growing interest in the synthesis of substituted pyrroles in the area of materials chemistry [13][14].…”