ChemInform Abstract: SYNTHESIS OF SCHIFF′S BASES AND THEIR REDUCTION

Sondhi, Sham M.; Bhatti, A. M.; Mahajan, Mohinder P.; Ralhan, N. K.

doi:10.1002/chin.197535253

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“…It should be noted that the structure of the products 67 was proven both by a complex of physicochemical methods ( 1 H, 13 C NMR, IR spectra) and by alternative synthesis with thiophosgene as a reagent. Sondhi et al 41 performed the reaction of 3-isothiocyanatobutanal (68) with aromatic, heteroaromatic, and aliphatic diamines with the aim to find compounds with analgesic and anti-inflammatory activity. It was shown that structure of the products greatly depended on the type of diamine used (Scheme 18).…”

Section: [5+1] Heterocyclizationmentioning

confidence: 99%

Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs

Voskoboynik

Kolomoets

Берест

et al. 2017

Chem Heterocycl Comp

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3+3] HeterocyclizationsAlthough the formation of 2-thioxo-or 2-mercaptopyrimidine system using [3+3] heterocyclization process has been less explored there are some published examples in literature. Thus, Miyamoto's 24 group had investigated the interaction of 2-(ethoxymethylidene)malononitrile (2) with methyl N'-cycloalkylylidenecarbamohydrazonothioates 1, which led to the formation of spirocondensed heterocyclic systems 3 containing pyrimidine ring (Scheme 1).The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer.

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Section: [5+1] Heterocyclizationmentioning

confidence: 99%