ChemInform Abstract: SYNTHESIS OF SOME NEWER FORMAZANS AND TETRAZOLIUM SALTS AND THEIR EFFECT ON RANIKHET DISEASE VIRUS AND THE VACCINIA VIRUS

Abstract

Die Hydrazone (I) bzw. (IV) wurden mit Ary1diazonium‐Salzen (II) zu den Formazanen (III) bzw. (V) umgesetzt.

Functionalized formazans: A review on recent progress in their pharmacological activities

“…The results revealed that the two compounds were found to exhibit significant activity 87% and 83%, respectively against the Ranikhet disease virus. However no activity against vaccinia virus could be observed [63] .…”

“…Some formazans possess antiviral activity [62,63] . For example, 1-(o-Carboxyphenyl)-3-(3′.4′-dimethoxy-6′-nitrophenyl)-5-phenylformazan 12 ( Chart 8 ), which was prepared by coupling of benzenediazonium chloride with the corresponding aldehyde N-(2-carboxyphenyl)hydrazone, was reported to exhibit 100% protection against the Ranikhet disease virus [62] .…”

“…Misra and Dhar [63] synthesized the two formazan derivatives 13 and 14 ( Chart 9 ) by coupling of the corresponding hydrazones each with benzene diazonium salt and screened them for their antiviral activity against vaccinia virus and Ranikhet disease virus in a stationary culture of chorioallantoic membrane of chick embryo. The results revealed that the two compounds were found to exhibit significant activity 87% and 83%, respectively against the Ranikhet disease virus.…”

Differential Effect of Tetrazolium Dyes upon Bacteriophage Plaque Assay Titers

“…coworkers are virus specific, and the compounds did not affect vaccinia virus (10,11). On the basis of these findings by Misra and coworkers, we decided to determine whether the use of tetrazolium dyes as medium additives has a suppressive effect upon bacteriophage plaque assay titers.…”

“…More recently, published dye concentrations range from 300 (15) to 50 (1) ,ug/ml. During the same intervening time period, Misra and coworkers (10,11) discovered that some tetrazolium compounds, and some formazans, possess antiviral activity against Ranikhet disease virus (Newcastle disease virus). The antiviral effects noted by Misra and * Corresponding author.…”