ChemInform Abstract: Synthesis of Spiro Compounds as Medicinal Agents; New Opportunities for Drug Design and Discovery. Part I: A Review

Molvi, Khurshid I.; Haque, Navedul; Awen, Bahlul Z.; Zameeruddin, Mohammad

doi:10.1002/chin.201525271

Cited by 20 publications

(19 citation statements)

References 28 publications

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“…The biological properties of spiro compounds containing cyclic structures are evident from their presence in many natural products (Molvi et al, 2014). This class of compounds possesses pharmacological and therapeutic properties which play a fundamental role in biological processes.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of 5′′-benzylidene-1′-methyl-4′-phenyltrispiro[acenaphthylene-1,2′-pyrrolidine-3′,1′′-cyclohexane-3′′,2′′′-[1,3]dioxane]-2,6′′-dione

Chandralekha¹,

Gavaskar

Sureshbabu

et al. 2016

Acta Cryst E

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In the title trispiro compound, both the methyl-substituted pyrrolidine and dioxalane rings adopt a twist conformation. The cyclopentanone ring of the acenapthylen-1-one system adopts flattened envelope conformation, and the cyclohexanone attached to the dioxalane ring adopts boat conformation. In the crystal, centrosymmetrically related molecules are linked into dimers forming rings of (10) graph-set motif, which are further connected into chains parallel to the b axis by C—H⋯O contacts forming rings of (8) graph-set motif.

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of 5′′-benzylidene-1′-methyl-4′-phenyltrispiro[acenaphthylene-1,2′-pyrrolidine-3′,1′′-cyclohexane-3′′,2′′′-[1,3]dioxane]-2,6′′-dione

Chandralekha¹,

Gavaskar

Sureshbabu

et al. 2016

Acta Cryst E

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“…This pathway results in DNA fragmentation, degradation of cytoskeletal and nuclear proteins, formation of apoptotic bodies, and finally uptake by phagocytic cells (32). Recent reports indicate that most spiro compounds induce apoptosis of cancer cells (33,34), but especially spiroisoxazolidine derivatives (35). Here, we performed annexin V-FITC/PI apoptosis assays and demonstrated that our spirobisheterocyclic compounds induced apoptosis of breast cancer cell lines.…”

Section: Discussionmentioning

confidence: 62%

Effects of Spiro-bisheterocycles on Proliferation and Apoptosis in Human Breast Cancer Cell Lines

Ramdani

Talhi

Taïbi

et al. 2016

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Spiro-bisheterocyclic compounds 2-7 were chemically synthesized. Cell proliferation was assessed by resazurin assay. Annexin V-FITC/ PI apoptosis assays was performed in order to demonstrate apoptotic effects of spiro-bisheterocyclic In breast cancer cell lines.Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to analyze the wild-type p53, MDM2, BAX and caspase 3 gene expression levels.

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“…Spiro heterocycles represent an important class of naturally occurring substances with biological activities and diversified pharmacological and therapeutical properties . In recent years, isatin‐related articles have been published on synthesis of spiro and multispiro heterocyclic compounds from isatin .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Spiro[indoline‐3,4′‐pyrano[3,2‐c]chromene]diones

Ghadiri

Bayat

Hosseini

2018

Journal of Heterocyclic Chem

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A new series of isatin-based spiro-fused derivatives were prepared, via three-component reaction of Nalkyl-1-(methylthio)-2-nitroethenamine derived from the addition of various amines to nitroketene dithioacetal with isatin derivatives and 4-hydroxycoumarin in ethanol as a solvent at reflux. The significant advantages of this protocol include simple operation under mild conditions, easy purification, good yields, and catalyst-free approach.

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ChemInform Abstract: Synthesis of Spiro Compounds as Medicinal Agents; New Opportunities for Drug Design and Discovery. Part I: A Review

Abstract: Review: 109 refs.

Cited by 20 publications

References 28 publications

Crystal structure of 5′′-benzylidene-1′-methyl-4′-phenyltrispiro[acenaphthylene-1,2′-pyrrolidine-3′,1′′-cyclohexane-3′′,2′′′-[1,3]dioxane]-2,6′′-dione

Crystal structure of 5′′-benzylidene-1′-methyl-4′-phenyltrispiro[acenaphthylene-1,2′-pyrrolidine-3′,1′′-cyclohexane-3′′,2′′′-[1,3]dioxane]-2,6′′-dione

Effects of Spiro-bisheterocycles on Proliferation and Apoptosis in Human Breast Cancer Cell Lines

Synthesis of Spiro[indoline‐3,4′‐pyrano[3,2‐c]chromene]diones

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