ChemInform Abstract: Synthesis of Thio‐heterocyclic Analogues from Baylis—Hillman Bromides as Potent Cyclooxygenase‐2 Inhibitors.

Abstract

Synthesis of Thio-heterocyclic Analogues from Baylis-Hillman Bromides as Potent Cyclooxygenase-2 Inhibitors. -20 Compounds of type (VI) are prepared and screened for their COX-1 and COX-2 inhibitory activities. Especially (VIa)-(VIg) show potent and selective COX-2 inhibition. -(SANTHOSHI, A.; MAHENDAR, B.; MATTAPALLY, S.; SADHU, P. S.; BANERJEE, S. K.; JAYATHIRTHA RAO*, V.; Bioorg. Med. Chem. Lett. 24 (2014) 8, 1952-1957, http://dx.doi.org/10.1016/j.bmcl.2014.02.073 ; Crop Prot. Chem., Indian Inst. Chem. Technol., Hyderabad 500 007, India; Eng.) -M. Bohle 38-082