Synthesis of Thio-heterocyclic Analogues from Baylis-Hillman Bromides as Potent Cyclooxygenase-2 Inhibitors. -20 Compounds of type (VI) are prepared and screened for their COX-1 and COX-2 inhibitory activities. Especially (VIa)-(VIg) show potent and selective COX-2 inhibition. -(SANTHOSHI, A.; MAHENDAR, B.; MATTAPALLY, S.; SADHU, P. S.; BANERJEE, S. K.; JAYATHIRTHA RAO*, V.; Bioorg. Med. Chem. Lett. 24 (2014) 8, 1952-1957, http://dx.doi.org/10.1016/j.bmcl.2014.02.073 ; Crop Prot. Chem., Indian Inst. Chem. Technol., Hyderabad 500 007, India; Eng.) -M. Bohle 38-082
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.