ChemInform Abstract: TETRAHYDRO‐1,3,5‐THIADIAZIN‐2‐THIONE MIT ANTIMYKOTISCHER, ANTIBAKTERIELLER UND ANTHELMINTISCHER WIRKSAMKEIT

Abstract

Zur Synthese von symm. substituierten Tetrahydro‐l ,3,5‐thiadiazin‐2‐thionen der allgemeinen Formel (IV) werden primäre Amine (I) mit CS2 zu den Ammoniumsalzen (II) umgesetzt und diese mit Formaldehyd (III) in (IV) übergeführt.

Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal agents

“…Antifungal compounds with a 1,3,5-thiadiazine core Compounds containing a 1,3,5-thiadiazine core have been demonstrated to possess antifungal properties. It has become well established that the 1,3,5-thiadiazine-2-thione moiety exhibits antifungal activity through the production of isothiocyanate and dithiocarbamic acids [69][70][71][72][73][74][75][76][77][78] In 2001, Hussein et al [79] reported on several new derivatives of the 1,3,5-thiadiazine-2-thione core. The study was based on introduction of two moieties of 1,3,5-thiadiazine-2-thione through an ethylene bridge and investigation of the antifungal activity of these structural analogues.…”

Synthesis, in vitro urease inhibitory activity and molecular docking of 3,5‐disubstituted thiadiazine‐2‐thiones

“…The thiadiazine thione nucleus and its derivatives have received particular attention due to its diverse range biological activities, most notably antibacterial, antifungal, antitubercular, anthelmintic, antiprotozoal, leishmanicidal, antimycobacterial, and antiviral…”

New Tetrahydro-2H-1,3,5-thiadiazine-2-thione Derivatives as Potential Antimicrobial Agents

“…On the other hand, among the reported tetrahydrothiadiazine 2-thiones [14][15][16][17][18][19][20][21][22][23][24][25][26] many of these THTT derivatives had shown antibacterial and/or antifungal activities [14][15][16][17][18][19][20][21] . This THTT system is characterized by the presence of a strong electron-withdrawing group (a thiocarbonyl group) at carbon 2.…”