ChemInform Abstract: THE CHEMISTRY OF 2H‐3,1‐BENZOXAZINE‐2,4(1H)DIONE (ISATOIC ANHYDRIDES) PART 1, THE SYNTHESIS OF N‐SUBSTITUTED 2H‐3,1‐BENZOXAZINE‐2,4(1H)DIONES

Hardtmann, Goetz E.; Koletar, G.; Pfister, Oskar R.

doi:10.1002/chin.197542293

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4-Aminomethylpyridine, reagents, and solvents were purchased from Aldrich. Compounds 1a-d, 12 2a,b, 21 3a-e, 13 6, 11 7, 12 9a-d, 13 11a, 22 and N-ethylisatoic anhydride 23 were prepared according to known procedures. 4-Aminomethylpyridine dihydrochloride (12) was obtained from the corresponding commercial amine as described for 10a-j.…”

Section: Methodsmentioning

confidence: 99%

Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases

et al. 2005

View full text Add to dashboard Cite

The first substratelike, reversible inhibitors of different copper amine oxidases (CAOs) with IC50 (M) as low as 2.0 x 10(-8) corresponding to derivatives of 4-aminomethylpyridine with alkoxy (1a-d), alkylthio (2a,b), and alkylamino (3a-e, 4a-j) groups in the positions 3 and 5 have been prepared and studied. The inhibitors 1a-d are active on benzylamine oxidase and semicarbazide-sensitive amine oxidase and are very selective with respect to diamine oxidase, lysyl oxidase, and monoamine oxidases. The inhibitors 2a,b are selective for benzylamine oxidase whereas 2a is also a new type of good substrate of diamine oxidase. The inhibitors 3a-e and 4a-j are substratelike, reversible, nonselective inhibitors of various CAOs including pea seedling amine oxidase and Hansenula polymorpha amine oxidase, whose enzymatic sites are known from X-ray structure determinations. The inhibitors 3b,c and 4b,c are excellent substratelike tools for studies correlating CAOs that afford crystals suitable for X-ray structure determinations with CAOs from mammals.

show abstract

Section: Methodsmentioning

confidence: 99%

Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases

et al. 2005

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: THE CHEMISTRY OF 2H‐3,1‐BENZOXAZINE‐2,4(1H)DIONE (ISATOIC ANHYDRIDES) PART 1, THE SYNTHESIS OF N‐SUBSTITUTED 2H‐3,1‐BENZOXAZINE‐2,4(1H)DIONES

Abstract: Zu pharmakologischen Untersuchungen wird eine Vielzahl (100) von Isatosäureanhydriden der allgemeinen Formel (IX) hergestellt.

Cited by 1 publication

References 1 publication

Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases

Alkylamino Derivatives of 4-Aminomethylpyridine as Inhibitors of Copper-Containing Amine Oxidases

Contact Info

Product

Resources

About