ChemInform Abstract: Total Synthesis of (R)‐Sarkomycin via Asymmetric Rhodium‐Catalyzed Conjugate Addition.

Westmeier, Johannes; Kress, Steffen; Pfaff, Christopher; Zezschwitz, Paultheo von

doi:10.1002/chin.201415235

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2019

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“…128 This strategy was later used in the enantioselective preparation of (R)-sarkomycin. 129 Nicolaou employed Rh-catalyzed asymmetric CAs of alkenylzirconium species with a subsequent aldol reaction in the total synthesis of an advanced intermediate of vannusal A. A one-pot reaction of cyclic and linear Michael acceptor with various aldehydes in the presence of alkenylzirconium by employing the catalytic system [Rh(cod)(MeCN) 2 ]BF 4 /(S)-L21 provided the desired products 130 in high yield, but with poor diastereoselectivity.…”

Section: ■ Introductionmentioning

confidence: 99%

Asymmetric Transition-Metal Catalysis in the Formation and Functionalization of Metal Enolates

et al. 2019

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This review comprises two major parts, which have chiral metal enolates as their focus. In the first part, we discuss transition-metal-catalyzed conjugate additions leading to chiral enolates, which are then subsequently functionalized by reactions with electrophiles, both further catalyzed or uncatalyzed. The second part deals with base-generated enolates and their use in asymmetric transition-metal-catalyzed processes.

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Section: ■ Introductionmentioning

confidence: 99%