ChemInform Abstract: Unexpected Formation of Pyridodiindole Derivatives with Cytotoxic Activity via Double Nenitzescu Reaction.

Abstract

Fused pyridine derivatives R 0450 Unexpected Formation of Pyridodiindole Derivatives with Cytotoxic Activity via Double Nenitzescu Reaction. -The reaction of triamine (II) with 2 equivalents of 1,4-benzoquinone (III) leads unexpectedly to a mixture of 1:1-adduct (IV) and 1:2-adducts (V)/(VI) [some yields not given]. Derivatives (V) and (VI) demonstrate cytotoxic activity against several human cancer cell lines. -(WILLEMANN, C.; WAIBEL, R.; GRUENERT, R.; BEDNARSKI, P.; TROSCHUETZ*, R.; J. Heterocycl. Chem. 45

Diverse outcomes of CO2 fixation using alkali metal amides including formation of a heterobimetallic lithium–sodium carbamato-anhydride via lithium–sodium bis-hexamethyldisilazide

“…27 Due to the widespread nature of the five membered ring, it should come as no surprise to find that N-CO 2 based structural motifs such as that seen in polymeric 1 are present in a variety of biologically active compounds, which have found use as potential cyclotoxic antitumor agents to antiretroviral therapies. 28,29 Next we turned to LDA. The reactive Li-N bond present would be ideal for use in CO 2 activation presumably furnishing the corresponding lithium carbamate complex.…”