ChemInform Abstract: Vilsmeier—Haack Formylation of Acetonitrile Revisited: Synthesis of Novel Pyrazolo[1,5‐a]pyrimidines and Triazolo[1,5‐a]pyrimidine.

Abstract

Fused pyrimidine derivatives R 0515Vilsmeier-Haack Formylation of Acetonitrile Revisited: Synthesis of Novel Pyrazolo[1,5-a]pyrimidines and Triazolo[1,5-a]pyrimidine. -The Vilsmeier-Haack formylation of acetonitrile (I) leads to formation of the highly stable synthon (III) which is utilized in the synthesis of pyrimidine-fused heterocycles like pyrazolopyrimidines (VI) and triazolopyrimidine (VIII). These heterocycles possibly exhibit a number of bioactivities, specifically inhibitory action against cAMP phosphodiesterase. -(GHAGARE, M. G.; BIRARI, D. R.; SHELAR, D. P.; TOCHE, R. B.; JACHAK*, M. N.; J. Heterocycl. Chem. 46 (2009) 2, 327-331; Org. Chem. Res.