Chemistry and Biochemistry of Terpenoids from<i>Curcuma</i>and Related Species

Afzal, Aqeela; Oriqat, Ghalib; Khan, Maria; Jose, Jacquilion; Afzal, Muhammad

doi:10.1080/22311866.2013.782757

Cited by 41 publications

(27 citation statements)

References 487 publications

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“…The antimicrobial activity of the crude extract could be due to the existence of other components of C. longa such as diarylpentanoids, monoterpenes, sesquiterpenes, diterpenes, triterpenoids, alkaloid and sterols (Li et al, 2011 ). For example, terpenoids from C. longa were reported to possess antibacterial killing of various pathogens (Afzal et al, 2013 ). Thus, UE-08 was omitted from further analysis.…”

Section: Resultsmentioning

confidence: 99%

Curcumin rescues Caenorhabditis elegans from a Burkholderia pseudomallei infection

Eng

Nathan

2015

Front. Microbiol.

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The tropical pathogen Burkholderia pseudomallei requires long-term parenteral antimicrobial treatment to eradicate the pathogen from an infected patient. However, the development of antibiotic resistance is emerging as a threat to this form of treatment. To meet the need for alternative therapeutics, we proposed a screen of natural products for compounds that do not kill the pathogen, but in turn, abrogate bacterial virulence. We suggest that the use of molecules or compounds that are non-bactericidal (bacteriostatic) will reduce or abolish the development of resistance by the pathogen. In this study, we adopted the established Caenorhabditis elegans-B. pseudomallei infection model to screen a collection of natural products for any that are able to extend the survival of B. pseudomallei infected worms. Of the 42 natural products screened, only curcumin significantly improved worm survival following infection whilst not affecting bacterial growth. This suggested that curcumin promoted B. pseudomallei-infected worm survival independent of pathogen killing. To validate that the protective effect of curcumin was directed toward the pathogen, bacteria were treated with curcumin prior to infection. Worms fed with curcumin-treated bacteria survived with a significantly extended mean-time-to-death (p < 0.0001) compared to the untreated control. In in vitro assays, curcumin reduced the activity of known virulence factors (lipase and protease) and biofilm formation. To determine if other bacterial genes were also regulated in the presence of curcumin, a genome-wide transcriptome analysis was performed on curcumin-treated pathogen. A number of genes involved in iron acquisition and transport as well as genes encoding hypothetical proteins were induced in the presence of curcumin. Thus, we propose that curcumin may attenuate B. pseudomallei by modulating the expression of a number of bacterial proteins including lipase and protease as well as biofilm formation whilst concomitantly regulating iron transport and other proteins of unknown function.

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Section: Resultsmentioning

confidence: 99%

Curcumin rescues Caenorhabditis elegans from a Burkholderia pseudomallei infection

Eng

Nathan

2015

Front. Microbiol.

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“…Several phytochemical studies on Curcuma oils led to the identification of sesquiterpenoids and monoterpenoids as the major components [ 9 ]. The essential oil (EO) of Curcuma species possesses a wide variety of pharmacological properties, including anti-inflammatory, anticancerous, antiproliferative, hypocholesterolemic, antidiabetic, antihepatotoxic, antidiarrheal, carminative, diuretic, antirheumatic, hypotensive, antioxidant, antimicrobial, antiviral, insecticidal, larvicidal, antivenomous, antithrombotic, antityrosinase, and cyclooxygenase-1 (COX-1) inhibitory activities, among others [ 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Curcuma oils are also known to enhance immune function, promote blood circulation, accelerate toxin elimination, and stimulate digestion [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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Members of the genus Curcuma L. have been used in traditional medicine for centuries for treating gastrointestinal disorders, pain, inflammatory conditions, wounds, and for cancer prevention and antiaging, among others. Many of the biological activities of Curcuma species can be attributed to nonvolatile curcuminoids, but these plants also produce volatile chemicals. Essential oils, in general, have shown numerous beneficial effects for health maintenance and treatment of diseases. Essential oils from Curcuma spp., particularly C. longa, have demonstrated various health-related biological activities and several essential oil companies have recently marketed Curcuma oils. This review summarizes the volatile components of various Curcuma species, the biological activities of Curcuma essential oils, and potential safety concerns of Curcuma essential oils and their components.

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“…26 Although terpenoid secondary products were observed only in the twigs extract, terpenoids have been reported to exert activity against cancer and bacteria. [27][28][29] Total phenolic and flavonoid contents The TPC of the extracts of L. Littorea was determined by the Folin-Ciocalteu method and values were between 567.22 to 2361.11 mg GAE/g crude extract. The extracts of bark and twig contained greater amounts of phenolics (2361.11 and 2160.56 mg GAE/g crude extract) compared to the flower and leaf extracts (1320.56 and 567.22 mg GAE/g crude extract) ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

Bio-Activity Investigations of Extracts of Different Parts of Lumnitzera littorea Voigt

2020

TJNPR

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Plants are a great source of potentially beneficial chemical compounds. They produce a wide variety of substances that are used for biological functions and for preventing diseases caused by pathogens, fungi and other sources. Traditionally, it has been a common practice to treat microbial infections such as whooping cough, or skin ailments, and inflammations with crude extracts or decoctions derived from plants. However, there has been information of phenolic or flavonoid acting as bioactive substance but none of an obvious experimental result to determine the type of bioactive substance helping to treat the symptoms. Several previous works reported that different parts of plants including bark, leaves, fruits, flowers, and seeds have phytochemical constituents with a variety of pharmacological properties. 1-4 These phytochemicals contain naturally bioactive compounds that are formed during a plant's normal metabolic processes and which are often referred to as secondary metabolites. These metabolites commonly include alkaloids, terpenoids, tannins, saponins, phenolics and flavonoids. These are widely used as lipase inhibitors, antioxidants and antimicrobial agents. 1-6 To identify bioactive compounds, phytochemical screening is the first and important step in isolating the type of secondary

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Chemistry and Biochemistry of Terpenoids fromCurcumaand Related Species

Cited by 41 publications

References 487 publications

Curcumin rescues Caenorhabditis elegans from a Burkholderia pseudomallei infection

Curcumin rescues Caenorhabditis elegans from a Burkholderia pseudomallei infection

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Bio-Activity Investigations of Extracts of Different Parts of Lumnitzera littorea Voigt

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