Chemistry of modified flavonoids 17. Imidazole analogs of flavonoids

Azolylimidazoles: Synthetic strategies and medicinal applications

“…In the same fashion, imidazolylpyrazoles 14 were prepared, in 65%-80% yields, by reaction of chalcone 13 with hydrazine hydrate in refluxing ethanol for 10-20 h followed by diluting with water (Scheme 5). 29 The reaction of β -diketones 20 with phenylhydrazine afforded 5-aryl-3-(1-methyl-5-nitro-2-imidazolyl)- Benzylideneimidazolylpyrazolinones 25, as potential antimicrobial and acetylcholinesterase inhibitory agents, were prepared from the corresponding benzylideneoxazolones 23 and the aminopyrazolone 24 (Scheme…”

“…Imidazolylisoxazoles 93 were prepared by reaction of C( α)-dianions of oximes 92 with electrophilicnucleophilic reagent ethyl 4-methyl-5-imidazolcarboxylate 27 in the presence of an excess amount of LDA (Scheme 31) 35,60. The reaction of 94 with hydroxylamine hydrochloride gave the imidazolylisoxazole 95 in 80% yield (Scheme 32) 29,61. Imidazolyltriazoles 113 were prepared by cyclocondensation reaction of 4-amino-5-cyanotriazoles 112 with diamines 111 in the presence of P 2 S 5 as catalyst (Scheme 35) 64.…”

Indolylimidazoles: Synthetic approaches and biological activities

“…has reported as an antibiotic and antitumor agent 28. Structure of 3-(4,5-Diphenyl-1H-imidazol-2-yl)-1H-indole Structure of 3-(1-(1,2,3,4-Tetrahydronaphthalen-1-yl)-1H-imidazole)-5-(benzyloxy)-1H-pyrrolo[2,3-c]-pyridine Rajaramana D., Sundararajana G. et al 29 described the synthesis of 3-{1-[2-(3,4dimethoxyphenyl)ethyl]-4,5-diphenyl-1H-imidazol-2-yl}-1H-indole (Fig.…”