Chemistry,<sub>13</sub>C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica

Wagner, Hildebert; Ott, S.; Jurcic, K.; Morton, J.; Neszmelyi, A.

doi:10.1055/s-2007-969908

Cited by 46 publications

(37 citation statements)

References 10 publications

(13 reference statements)

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“…It has been reported that quercetin and kaempferol possess anxiolytic and sedative activities (AguirreHernández et al, 2010;Jäger and Saaby, 2011). Saponins are also found to exhibit sedative activity (Wagner et al, 1983). Considering our results and previously published reports, it can be suggested that the anxiolytic and sedative activities observed for the plant extract might be due to the presence of CNS active compounds.…”

Section: Resultssupporting

confidence: 78%

Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

Islam¹,

Shajib²,

Datta³

et al. 2018

Bangla Pharma J

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Albizia lebbeck (Linn.) Benth. is a deciduous tree which is planted as ornamental and avenue tree almost all over Bangladesh. Leaves of the plant are used in ethnomedicine for the treatment of convulsion and CNS related disorder. This study was aimed to evaluate the neuropharmacological effects of the methanol extract of A. lebbeck leaves in Swiss albino mice. The locomotor effect of crude methanol extract of the plant was investigated by open field and hole cross tests while the anxiolytic activity was determined using elevated plus-maze (EPM) and light/dark box (LDB) tests. Furthermore, the sedative activity of the plant extract was assessed by sodium thiopental-induced sleeping time test. The results demonstrated that the methanol extract significantly (p < 0.001) reduced locomotion of the animals in both hole cross and open field tests in dose-dependent manner at 200-400 mg/kg b.w. In both EPM and LDB tests, the plant extract produced significant anxiolytic effect (p < 0.05) at the doses of 100-400 mg/kg b.w. In addition, it showed significant (p < 0.001) dose-dependent decrease in the onset of sleep and an increase in duration of sleep in sodium thiopental-induced sleeping time test. Preliminary phytochemical analyses of the plant extract revealed the presence of alkaloid, flavonoid, glycoside, saponin, tannin and resin. In acute toxicity test, the leaf extract did not exhibit any adverse effect in mice during 7 days treatment. The results of the present studies suggest that the crude methanol extract of A. lebbeck leaves possesses significant CNS depressant, anxiolytic and sedative properties and rationalize the traditional uses of the plant.

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Section: Resultssupporting

confidence: 78%

Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

Islam¹,

Shajib²,

Datta³

et al. 2018

Bangla Pharma J

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“…Flavonoids and their related compounds also exhibit inhibition of arachidonic acid peroxidation, which results in reduction of prostaglandin levels thus reducing the fever and pain (Baumann et al, 1980). Saponins have been implicated in opioid receptor mechanism (Huong et al, 1995) through antagonistic activity (Wagner et al, 1983) by binding on the sensory nerve terminals. It suggests that flavonoids and saponins were responsible for the antipyretic and antinociceptive effects of N. latifolia roots decoction.…”

Section: Pharmaceutical Biologymentioning

confidence: 99%

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Taïwé¹,

Bum

Talla

et al. 2010

Pharmaceutical Biology

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“…Nevertheless, these compounds also exhibit a variety of pharmacological properties such as analgesic (Gene et al, 1996), antiulcerogenic (Wrzeciono et al, 1985), sedative (Wagner et al, 1983) and corticosterone secretion-induction properties (Yokoyama et al, 1982). In addition, a preliminary screening of the extracts from approximately 400 different plants led to the discovery of myricerone caffeoyl ester (1), a triterpene derivative isolated from a crude extract of twigs of the southern bayberry (Myrica cerifera), which showed high specificity for the human endothelin type A receptor (Fujimoto et al, 1992;Mihara and Fujimoto, 1993;Maguire et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ET_A and angiotensin AT₁ receptors

Caballero‐George¹,

Vanderheyden²,

Okamoto³

et al. 2004

Phytotherapy Research

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Different types of triterpenes including saponins and aglycons were evaluated for their ability to inhibit [ 3 H] BQ-123 and [3 H] angiotensin II binding to the human endothelin 1 ET A and angiotensin II AT 1 receptors, respectively. Selectivity for only one of the two receptors was exhibited by asiatic acid and its saponins (ET A ) and oleanolic acid (AT 1 ). To a lesser extent betulinic acid, β β β β β-amyrin and friedelin also showed selectivity for the ET A receptor. To address the question whether the effect of saponins on cell membranes might interfere with the normal binding of specific radioligands to their receptors, the activity of saponins with different haemolytic properties were compared. Highly haemolytic saponins such as α α α α α-hederin and β β β β β-escine showed partial (60%) inhibition of radioligand-binding to the ET A receptor and complete inhibition (100%) to the AT 1 receptor. Moreover, the haemolytically inactive kryptoescine, at the same concentration, caused complete inhibiton of radioligand-binding to both receptors, indicating that inhibition of receptor binding was not related to the membrane-interacting properties of saponins.

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Chemistry,₁₃C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica

Cited by 46 publications

References 10 publications

Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ET_A and angiotensin AT₁ receptors

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Chemistry,13C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica

Cited by 46 publications

References 10 publications

Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors

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Product

Resources

About

Chemistry,₁₃C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica

Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ET_A and angiotensin AT₁ receptors