2011
DOI: 10.4161/cbt.11.2.13798
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Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy

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Cited by 82 publications
(56 citation statements)
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“…For example, 4-methylcatechol (a metabolite of quercetin) has been shown to induce the intrinsic apoptotic pathway in metastatic melanoma cells 22 . Serving as an example of the beneficial effects of CUR in the medical clinic, the combination of CUR and TAM has been shown to increase phosphatidylserine flipping, mitochondria depolarization and the generation of reactive oxygen species in chemo-resistant melanoma 23 . Part of the cytotoxic activity of VAN on tumour cells is also due to its inhibition of NF-κB activation, which results in enhanced TRAIL-induced apoptotic cell death 24 as well as cytolytic and cytostatic effects 25 .…”
Section: Discussionmentioning
confidence: 99%
“…For example, 4-methylcatechol (a metabolite of quercetin) has been shown to induce the intrinsic apoptotic pathway in metastatic melanoma cells 22 . Serving as an example of the beneficial effects of CUR in the medical clinic, the combination of CUR and TAM has been shown to increase phosphatidylserine flipping, mitochondria depolarization and the generation of reactive oxygen species in chemo-resistant melanoma 23 . Part of the cytotoxic activity of VAN on tumour cells is also due to its inhibition of NF-κB activation, which results in enhanced TRAIL-induced apoptotic cell death 24 as well as cytolytic and cytostatic effects 25 .…”
Section: Discussionmentioning
confidence: 99%
“…Recent data has revealed the critical role of autophagy in cancer (46 -47). Curcumin was found to be able to activate autophagy in some types of cancer cells, including melanoma cells (29), colon cancer cells (30), and hepatocellular carcinoma cells (31). We noted that there was one previous report showing that H441 lung cancer cells displayed autophagic phenotype upon treatment of 3,5-bis(benzylidene)-4-piperidones, synthetic analogs of curcumin, under observation with electron microscopy (48).…”
Section: Discussionmentioning
confidence: 99%
“…Aoki et al firstly showed that curcumin suppressed the growth of malignant gliomas through induction of autophagy (28). In recent two years, this effect of curcumin was confirmed in melanoma cells (29), colon cancer cells (30), and hepatocellular carcinoma cells (31).…”
Section: Introductionmentioning
confidence: 91%
“…3,4 In addition, studies have demonstrated that curcumin is an efficient molecule for overcoming multidrug resistance phenomena as well as inducing sensitization of tumor cells for chemotherapy and radiation. [5][6][7][8][9][10] Unfortunately, the strong potential Uptake was determined by recording absorption of acetone cell lysates at λmax 450 nm using UV-vis spectrophotometer. Notes: Data are reported as the mean of three repeats for each uptake (mean ± standard error of the mean deviation; *P , 0.05, curcumin nanoformulations versus free curcumin).…”
Section: Introductionmentioning
confidence: 99%