Chemokine Signaling Mediates Self-Organizing Tissue Migration in the Zebrafish Lateral Line

Haas, Petra de; Gilmour, Darren

doi:10.1016/j.devcel.2006.02.019

Cited by 485 publications

(574 citation statements)

References 28 publications

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“…2J, arrows), suggesting that SDF1/CXCR4 and Wnt/LEF1 signaling redundantly repress this gene in the leading cells. We cannot rule out, however, the alternative possibility that cxcr7b expressing cells are transiently present in the leading region due to abnormal cell movement within the primordium (Haas and Gilmour, 2006). Contrary to cxcr4b, cxcr7b is not expressed at all at the early stage where cxcr4b is ubiquitously expressed (Fig.…”

Section: Developmental Dynamicsmentioning

confidence: 92%

“…We therefore repeated the experiment in 26 hpf embryos that were doubly transgenic for cxcr4b:rfp and for cldnb:gfp, where all cells of the PLL system express a membranebound green fluorescent protein (GFP; Haas and Gilmour, 2006). We observed that the level of red fluorescence at 26 hpf was reduced by 50% in morphant vs. control embryos (Figs.…”

Section: Lef1 Is Required For Cell Proliferation In the Pll Placodementioning

confidence: 99%

“…Patterning defects and gene expression patterns were examined in either the golden or the cldnb:gfp line (Haas and Gilmour, 2006). Fluorescence analysis was done in embryos resulting from a cross between homozygous cxcr4b:rfp (Gamba et al, 2010) and cldnb:gfp homozygous line (Haas and Gilmour, 2006).…”

Section: Experimental Procedures Fish Strainsmentioning

confidence: 99%

“…Fluorescence analysis was done in embryos resulting from a cross between homozygous cxcr4b:rfp (Gamba et al, 2010) and cldnb:gfp homozygous line (Haas and Gilmour, 2006). Ages are expressed as hours (hpf) or days (dpf) postfertilization.…”

Section: Experimental Procedures Fish Strainsmentioning

confidence: 99%

“…The embryonic PLL is generated by a sensory primordium, which migrates along a defined pathway, from the head to the tip of the tail (Harrison, 1904;Stone, 1937;Metcalfe, 1985). In zebrafish, primordium migration depends on SDF1 signaling by cells along the path of migration (David et al, 2002;Li et al, 2004;Haas and Gilmour, 2006; reviewed in Ghysen and Dambly-Chaudière, 2007). The direction of migration depends on the anisotropic distribution of two SDF1 receptors, CXCR4 which is present in the leading two-thirds of the primordium, and CXCR7 which is present in the trailing third Valentin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish

Gamba¹,

Cubedo²,

Lutfalla³

et al. 2010

Developmental Dynamics

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The embryonic development of the posterior lateral line of zebrafish involves the migration from head to tail of a primordium comprising approximately 100 cells, and the deposition at regular intervals of presumptive mechanosensory organs (neuromasts). Migration depends on the presence of chemokine SDF1 along the pathway, and on the asymmetrical distribution of chemokine receptors CXCR4 and CXCR7 in the primordium. Primordium polarization depends on Wnt signaling in the leading region. Here, we examine the role of a major effector of Wnt signaling, lef1, in this system. We show that, although its inactivation has no overt effect on the expression of cxcr4b and cxcr7b, lef1 contributes to their control. We also show that cell proliferation, which ensures constant primordium size despite successive rounds of cell deposition, is reduced upon lef1 inactivation. Because of this defect, the primordium runs short of cells and vanishes before the line has been completed. We conclude that lef1-mediated Wnt signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy. Developmental Dynamics 239:3163-3171,

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Section: Developmental Dynamicsmentioning

confidence: 92%

Section: Lef1 Is Required For Cell Proliferation In the Pll Placodementioning

confidence: 99%

Section: Experimental Procedures Fish Strainsmentioning

confidence: 99%

Section: Experimental Procedures Fish Strainsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish

Gamba¹,

Cubedo²,

Lutfalla³

et al. 2010

Developmental Dynamics

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Ear and Lateral Line of Vertebrates: Organisation and Development

Harding

McCarroll

McGraw

et al. 2013

Encyclopedia of Life Sciences

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In vertebrates, perception of movement and sound is accomplished by the lateral line and inner ear sensory systems. These systems sense reverberations, movement and acceleration by transducing mechanical stimuli from the environment into electrical signals by means of mechanosensory hair cells. Vestibular and auditory hair cells have associated sensory neurons that transmit these signals from the periphery to the central nervous system. During development, cranial sensory systems arise from an initially homogeneous population of cells that ultimately give rise to discrete sensory structures. Although the demands for auditory and vestibular sensation differ between species and environments, vertebrates use common cell types, genetic programmes and molecules to achieve the development of these mechanosensory organs. In this article, the structure and function of the mechanosensory hair cells, lateral line and inner ear and how these systems develop across species are discussed, and as well as the innervation of these systems. Key Concepts: The vertebrate inner ear is composed of both auditory and vestibular components. Both the lateral line and the inner ear are derived from embryonic structures known as cranial placodes. All cranial placodes originate from a homogenous group of cells known as the preplacodal ectoderm. Hair cells are structurally and functionally similar in both auditory and lateral line systems. The adult lateral line mediates sensation of movement in the aquatic environment of fishes and frogs. Embryonic posterior lateral line development is accomplished by the pre‐patterned posterior lateral line primordium. The lateral line is an experimentally accessible model for studying mechanosensory system development and biology.

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