Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis

Kraemer, Lucas; McKay, Derek M.; Russo, Remo Castro; Fujiwara, Ricardo Toshio

doi:10.1016/j.cytogfr.2022.05.002

Cited by 11 publications

(4 citation statements)

References 147 publications

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“…IL-8 was also elevated to a NPX around 12 in most CSDHs. IL-8 is known to be a proinflammatory chemokine that mainly attracts neutrophils (Edlmann et al, 2017;Holl et al, 2018;Kraemer et al, 2022). Frati et al found that higher IL-6 and IL-8 in the CSDH fluid was more frequent in the layered than the trabeculated CSDH subtype and also correlated with a greater risk of recurrence (Frati et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…All of these are important chemoattractors of inflammatory cells with some variations in their preference for specific cell types. For example, CCL3 is known to recruit monocytes, CCL3 to recruit eosinophils, and CXCL1 to recruit leukocytes (Kraemer et al, 2022). Particularly, eosinophils seem to be important in CSDH development as they promote fibrosis of the CSDH membrane and induce local coagulopathy by plasminogen release (Holl et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Among the different CSDH subtypes, CXCL1, CXCL5, and MCP-3 were higher in the presence of focal septa in the vicinity of the CSDH collection below the burr holes. CXCL1 is familiar to IL-8 and attracts leukocytes (Kraemer et al, 2022), whereas CXCL5 is more indicative of eosinophils, and MCP-3 of leukocytes (Kraemer et al, 2022), which may all contribute to the membranous growth. We also detected several angiogenic biomarkers.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory biomarkers differentiate the stage of maturation in chronic subdural hematomas

Wettervik¹,

Sundblom²,

Ronne-Engström³

2023

Journal of Neuroimmunology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory biomarkers differentiate the stage of maturation in chronic subdural hematomas

Wettervik¹,

Sundblom²,

Ronne-Engström³

2023

Journal of Neuroimmunology

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“…The increased IL-5 production is likely related to eosinophil-mediated destruction of O. viverrini , supported by reports of eosinophils killing Schistosoma mansoni through antibody-dependent cell-mediated cytotoxicity mechanisms [ 30 ]. IL-10 induction enhances Th2 differentiation and downregulates Th1 cytokine responses, thereby promoting worm expulsion in various helminth infections [ 31 – 33 ]. Interestingly, our hamster model exhibited opposite responses, with the inflammatory process persistently increasing during the late phase of infection.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the relationship among inflammatory responses, oxidative damage, and host susceptibility to Opisthorchis viverrini infection: A comparative analysis in animal models

Tangkawattana,

Suyapoh,

Taiki

et al. 2023

Vet World

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Background and Aim: Opisthorchis viverrini infection-induced inflammation contributes to cholangiocarcinoma (CCA) development in humans and animals. Inflammation generates free radicals, such as reactive oxygen species and reactive nitrogen species (RNS), which damage the host’s DNA. However, only 5% of O. viverrini-infected individuals develop malignancy, suggesting that variations in the inflammatory response of individuals to the parasite may influence susceptibility. Due to limitations in studying human susceptibility, we used an animal model to investigate the profiles of inflammatory reactions, oxidative burst, and irreversible DNA damage. This study aimed to explore the potential role of inflammation and RNS in causing DNA damage that may predispose susceptible hosts and non-susceptible animal models to cancer development in O. viverrini infection. Materials and Methods: This experimental study was conducted on 30 Syrian golden hamsters (OV-H) and 30 BALB/c mice (OV-M) infected with O. viverrini, representing susceptible and non-susceptible models, respectively. Five animals per group were examined at six predetermined time points during the experiment. Biliary tract samples were systematically investigated using histopathological evaluation for inflammatory cell infiltration and immunohistochemical staining for RNS production and markers of DNA damage, including nitrotyrosine and 8-hydroxy-2ʹ-deoxyguanosine. These features were quantified and compared among the experimental groups. Mann–Whitney U-test was used for statistical analysis, with p < 0.05 considered statistically significant. Results: The comparison revealed that the OV-M group exhibited significantly earlier and higher rates of inflammatory cell infiltration during the acute phase, whereas the OV-H group exhibited chronic and more severe inflammation (p < 0.020). Intracellular RNS production and DNA damage were closely associated with the inflammatory response. Conclusion: This study demonstrates differential responses in susceptible and non-susceptible models of O. viverrini infection regarding disease onset and duration, as well as intracellular RNS production and DNA damage caused by inflammation. Persistent inflammation generated oxidatively damaged DNA, which is a distinct pathological characteristic of susceptible hosts and may be critical for CCA development. Keywords: cholangiocarcinoma, DNA damage, inflammatory reactions, Syrian golden hamsters.

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Assessing the causal relationship between immune cells and prostatitis: evidence from bidirectional mendelian randomization analysis

Qu,

Jiang,

Long

et al. 2024

Mamm Genome

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Chemokines and chemokine receptors: Insights from human disease and experimental models of helminthiasis

Cited by 11 publications

References 147 publications

Inflammatory biomarkers differentiate the stage of maturation in chronic subdural hematomas

Inflammatory biomarkers differentiate the stage of maturation in chronic subdural hematomas

Unraveling the relationship among inflammatory responses, oxidative damage, and host susceptibility to Opisthorchis viverrini infection: A comparative analysis in animal models

Assessing the causal relationship between immune cells and prostatitis: evidence from bidirectional mendelian randomization analysis

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